Detail publikace

Mitochondria morphology and membrane potential under stress conditions

EZATI, M. ZUMBERG, I. ČMIEL, V.

Originální název

Mitochondria morphology and membrane potential under stress conditions

Typ

článek ve sborníku ve WoS nebo Scopus

Jazyk

angličtina

Originální abstrakt

Mitochondria, organelles found in the cytoplasm of almost all eukaryotic cells, generate large quantities of energy in the form of adenosine triphosphate (ATP). In addition to producing energy, mitochondria store calcium for cell signaling activities and play an important role in maintenance of ionic balance. Mitochondria, however, are highly sensitive to any kind of stress in which they mainly response by disturbance of respiration, reactive oxygen species (ROS) production and release of cytochrome c into the cytoplasm. Osmotic stress, in particular, generates ROS that degrade lipids, proteins, and DNA. High levels of salt concentration can cause an imbalance in cellular ion homeostasis that results in ion toxicity and osmotic stress. This study aims to investigate possible effects of KCl and NaCl on Bone marrow-derived (MSCs) mitochondria membrane potential (MMP) and morphology. The results indicated that KCl and NaCl of salt concentration can cause an imbalance in cellular ion homeostasis that results in ion toxicity and osmotic stress. This study aims to investigate possible effects of KCl and NaCl on MSCs mitochondria membrane potential (MMP) and morphology. The results indicated that KCl and NaCl decreased the potential and changed the morphology of mitochondria membrane compared to cells growing in normal condition.

Klíčová slova

Mitochondria membrane potential, Mitochondria morphology, Osmotic stress, Mitochondria fusion

Autoři

EZATI, M.; ZUMBERG, I.; ČMIEL, V.

Vydáno

26. 4. 2022

Nakladatel

Brno University of Technology, Faculty of Electrical Engineering and Communication

Místo

Brno

ISBN

978-80-214-6029-4

Kniha

Proceedings I of the 28th Conference STUDENT EEICT 2022 General Papers

Číslo edice

1

Strany od

432

Strany do

436

Strany počet

5

URL

https://www.eeict.cz/eeict_download/archiv/sborniky/EEICT_2022_sbornik_1_v2.pdf

BibTex

@inproceedings{BUT177723,
  author="Masoumeh {Ezati} and Inna {Zumberg} and Vratislav {Čmiel}",
  title="Mitochondria morphology and membrane potential under stress conditions",
  booktitle="Proceedings I of the 28th Conference STUDENT EEICT 2022 General Papers",
  year="2022",
  number="1",
  pages="432--436",
  publisher="Brno University of Technology, Faculty of Electrical Engineering and Communication",
  address="Brno",
  isbn="978-80-214-6029-4",
  url="https://www.eeict.cz/eeict_download/archiv/sborniky/EEICT_2022_sbornik_1_v2.pdf"
}