Diffusion of pharmaceuticals in agarose hydrogels enriched by humic acids

abstrakt

angličtina

The use of many different pharmaceuticals in medicine can result in potential dangerous behaviour in soil and aqueous environments [1]. Drugs are not completely eliminated in human body, therefore their residues can leave the body and pass into water, sediments and soils [2,3]. The potential degradation of drugs depends on their chemical character and physicochemical properties of their environment as e.g. soil properties and quality of organic matter. The migration ability and toxicity of pharmaceuticals in nature can be significantly affected by their interactions with soil components. Sulfonamides are one of the most commonly used antibiotic in human and veterinary medicine. Their overuse and misuse led to their widespread occurrence in nature [4,5]. In this contribution, sulfamethoxazole and sulphapyridine were used as representative of them. Diffusion experiments in agarose hydrogels and the hydrogels enriched by humic acids were realized. Pharmaceuticals diffused from saturated solutions into hydrogels and (in the case of enriched hydrogels) interacted with humic acids. A part of drugs such was immobilized which influenced the value of diffusion coefficients. Diffusion coefficients were determined for pure agarose hydrogels as well as for hydrogels containing humic acids and compared. The portion of free movable and immobilized pharmaceuticals and apparent equilibrium constant between free and bound drugs were calculated.

pharmaceuticals; diffusion; agarose; hydrogel; humic acids

KLUČÁKOVÁ, M.; ZÁVODSKÁ, P.

3. 9. 2022

University of Crete

Chania

348

348

1