Detail publikace

Antibacterial Electrospun Polycaprolactone Nanofibers Reinforced by Halloysite Nanotubes for Tissue Engineering

KHUNOVÁ, V. KOVÁČOVÁ, M. OLEJNÍKOVÁ, P. ONDREÁŠ, F. ŠPITÁLSKY, Z. GHOSAL, K. BERKEŠ, D.

Originální název

Antibacterial Electrospun Polycaprolactone Nanofibers Reinforced by Halloysite Nanotubes for Tissue Engineering

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Due to its slow degradation rate, polycaprolactone (PCL) is frequently used in biomedical applications. This study deals with the development of antibacterial nanofibers based on PCL and halloysite nanotubes (HNTs). Thanks to a combination with HNTs, the prepared nanofibers can be used as low-cost nanocontainers for the encapsulation of a wide variety of substances, including drugs, enzymes, and DNA. In our work, HNTs were used as a nanocarrier for erythromycin (ERY) as a model antibacterial active compound with a wide range of antibacterial activity. Nanofibers based on PCL and HNT/ERY were prepared by electrospinning. The antibacterial activity was evaluated as a sterile zone of inhibition around the PCL nanofibers containing 7.0 wt.% HNT/ERY. The morphology was observed with SEM and TEM. The efficiency of HNT/ERY loading was evaluated with thermogravimetric analysis. It was found that the nanofibers exhibited outstanding antibacterial properties and inhibited both Gram- (Escherichia coli) and Gram+ (Staphylococcus aureus) bacteria. Moreover, a significant enhancement of mechanical properties was achieved. The potential uses of antibacterial, environmentally friendly, nontoxic, biodegradable PCL/HNT/ERY nanofiber materials are mainly in tissue engineering, wound healing, the prevention of bacterial infections, and other biomedical applications.

Klíčová slova

biocompatible; antibacterial; halloysite; erythromycin; polycaprolactone; nanofibers; electrospinning; tissue engineering

Autoři

KHUNOVÁ, V.; KOVÁČOVÁ, M.; OLEJNÍKOVÁ, P.; ONDREÁŠ, F.; ŠPITÁLSKY, Z.; GHOSAL, K.; BERKEŠ, D.

Vydáno

1. 2. 2022

Nakladatel

MDPI

Místo

BASEL

ISSN

2073-4360

Periodikum

Polymers

Ročník

14

Číslo

4

Stát

Švýcarská konfederace

Strany od

746

Strany do

757

Strany počet

12

URL

https://www.mdpi.com/2073-4360/14/4/746

Plný text v Digitální knihovně

http://hdl.handle.net/11012/209170

BibTex

@article{BUT179280,
  author="Viera {Khunová} and Maria {Kováčová} and Petra {Olejníková} and František {Ondreáš} and Zdenko {Špitálsky} and Kajal {Ghosal} and Dušan {Berkeš}",
  title="Antibacterial Electrospun Polycaprolactone Nanofibers Reinforced by Halloysite Nanotubes for Tissue Engineering",
  journal="Polymers",
  year="2022",
  volume="14",
  number="4",
  pages="12",
  doi="10.3390/polym14040746",
  issn="2073-4360",
  url="https://www.mdpi.com/2073-4360/14/4/746"
}