Detail publikace

Dried Blood Spot Self-Sampling with Automated Capillary Electrophoresis Processing for Clinical Analysis

RYŠAVÁ, L. DVOŘÁK, M. KUBÁŇ, P.

Originální název

Dried Blood Spot Self-Sampling with Automated Capillary Electrophoresis Processing for Clinical Analysis

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

A simple and convenient concept of blood sampling followed by a fully automated analysis is presented. A disposable sampling kit is used for accurate self-sampling of capillary blood from a finger prick. A high-throughput blood sampling is thus enabled, which is essential in many clinical assays and considerably improves life quality and comfort of involved subjects. The collected blood samples are mailed to a laboratory for a fully automated dried blood spot (DBS) processing and analysis, which are performed with a commercial capillary electrophoresis instrument. Quantitative results are obtained within 20 min from the DBS delivery to the laboratory. The presented concept is exemplified by the determination of warfarin blood concentrations and demonstrates excellent analytical performance. Moreover, this concept is generally applicable to a wide range of endogenous and exogenous blood compounds and represents a novel and attractive analytical tool for personalized health monitoring.

Klíčová slova

analytical methods; blood self-sampling; dried blood spots; electrophoresis; warfarin

Autoři

RYŠAVÁ, L.; DVOŘÁK, M.; KUBÁŇ, P.

Vydáno

8. 3. 2021

Nakladatel

WILEY-V C H VERLAG GMBH

Místo

WEINHEIM

ISSN

1433-7851

Periodikum

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ročník

60

Číslo

11

Stát

Spolková republika Německo

Strany od

6068

Strany do

6075

Strany počet

8

URL

https://onlinelibrary.wiley.com/doi/full/10.1002/anie.202012997

BibTex

@article{BUT182858,
  author="Lenka {Ryšavá} and Miloš {Dvořák} and Pavel {Kubáň}",
  title="Dried Blood Spot Self-Sampling with Automated Capillary Electrophoresis Processing for Clinical Analysis",
  journal="ANGEWANDTE CHEMIE-INTERNATIONAL EDITION",
  year="2021",
  volume="60",
  number="11",
  pages="6068--6075",
  doi="10.1002/anie.202012997",
  issn="1433-7851",
  url="https://onlinelibrary.wiley.com/doi/full/10.1002/anie.202012997"
}