Detail publikace

Faradaic Fenton Pixel: Reactive Oxygen Species Delivery Using Au/Cr Electrochemistry

MIGLBAUER, E. ABUDLLAEVA, O. GRYSZEL, M. GLOWACKI, E.

Originální název

Faradaic Fenton Pixel: Reactive Oxygen Species Delivery Using Au/Cr Electrochemistry

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Reactive oxygen species (ROS) are an integral part of many anticancer therapies. Fenton-like processes involving reactions of peroxides with transition metal ions are a particularly potent and tunable subset of ROS approaches. Precise on-demand dosing of the Fenton reaction is an area of great interest. Herein, we present a concept of an electrochemical faradaic pixel that produces controlled amounts of ROS via a Fenton-like process. The pixel comprises a cathode and anode, where the cathode reduces dissolved oxygen to hydrogen peroxide. The anode is made of chromium, which is electrochemically corroded to yield chromium ions. Peroxide and chromium interact to form a highly oxidizing mixture of hydroxyl radicals and hexavalent Cr ions. After benchmarking the electrochemical properties of this type of device, we demonstrate how it can be used under in vitro conditions with a cancer cell line. The faradaic Fenton pixel is a general and scalable concept that can be used for on-demand delivery of redox-active products for controlling a physiological outcome.

Klíčová slova

bioelectronics; Fenton reaction; oxygen reduction reaction; reactive oxygen species

Autoři

MIGLBAUER, E.; ABUDLLAEVA, O.; GRYSZEL, M.; GLOWACKI, E.

Vydáno

1. 9. 2023

Nakladatel

Wiley-VCH

Místo

WEINHEIM

ISSN

1439-7633

Periodikum

Chembiochem : a European journal of chemical biology

Ročník

24

Číslo

17

Stát

Spolková republika Německo

Strany od

1

Strany do

14

Strany počet

14

URL

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202300353

Plný text v Digitální knihovně

http://hdl.handle.net/11012/245065

BibTex

@article{BUT184657,
  author="Eva {Miglbauer} and Oliya S. {Abudllaeva} and Maciej {Gryszel} and Eric Daniel {Glowacki}",
  title="Faradaic Fenton Pixel: Reactive Oxygen Species Delivery Using Au/Cr Electrochemistry",
  journal="Chembiochem : a European journal of chemical biology",
  year="2023",
  volume="24",
  number="17",
  pages="14",
  doi="10.1002/cbic.202300353",
  issn="1439-7633",
  url="https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cbic.202300353"
}