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JAGOŠ, J. KOHÚT, J. NOVOTNÝ, T. KŘIVKA, T. HÁJEK, P. FORMÁNEK, M. BURŠA, J.
Originální název
IN SILICO HEMODYNAMICAL SIMULATIONS SHOW SECONDARY BENEFITS OF ANTIHYPERTENSIVE DRUGS
Typ
článek ve sborníku mimo WoS a Scopus
Jazyk
angličtina
Originální abstrakt
Although preventable, hypertension and hypertensive renal disease remain one of the major global risk factors for cardiovascular diseases, especially in the developed world [1]. Hypertension is defined as a chronically increased blood pressure (BP) above 140/90 mmHg and is related to an increase in peripheral resistance and decrease in arterial distensibility [2], similarly to an aging [1]. Available evidence confirms the ability of all five basic groups of antihypertensives to decrease arterial stiffness and consequently the BP in the long-term application [3]. Although proper treatment of hypertension attenuates its influence, the mechanisms by which hypertension accelerates atherosclerosis are poorly understood [4]. It is known that flow waveform for older subjects differs substantially from the young one mainly due to elevated arterial stiffness and consequently early wave reflection [5]. Moreover, the decreasing arterial stiffness via proper treatment of hypertension shifts the shape of the flow waveform to a young and healthy one [6]. Since arterial stiffness can be lowered through long-term application of antihypertensives, benefits of medical therapy could be not only in lowering the BP and peripheral resistance but also in improving the hemodynamic conditions.
Klíčová slova
HEMODYNAMICAL SIMULATIONS; ANTIHYPERTENSIVE DRUGS
Autoři
JAGOŠ, J.; KOHÚT, J.; NOVOTNÝ, T.; KŘIVKA, T.; HÁJEK, P.; FORMÁNEK, M.; BURŠA, J.
Vydáno
9. 7. 2023
Místo
Maastricht
Strany počet
1
URL
https://esbiomech.org/conference/wp-content/uploads/2023/ESB2023_Book_of_Abstracts.pdf
BibTex
@inproceedings{BUT184917, author="Jiří {Jagoš} and Jiří {Kohút} and Tomáš {Novotný} and Tomáš {Křivka} and Petr {Hájek} and Martin {Formánek} and Jiří {Burša}", title="IN SILICO HEMODYNAMICAL SIMULATIONS SHOW SECONDARY BENEFITS OF ANTIHYPERTENSIVE DRUGS", booktitle="ESB 2023 BOOK OF ABSTRACTS", year="2023", number="28", pages="1", address="Maastricht", url="https://esbiomech.org/conference/wp-content/uploads/2023/ESB2023_Book_of_Abstracts.pdf" }