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VERČIMÁKOVÁ, K. KARBOWNICZEK, J. STACHEWICZ, U. VOJTOVÁ, L.
Originální název
BIOMECHANICAL AND STRUCTURAL EVALUATION OF THE EFFECT OF GLYCEROL ON A RESORABLE CHITOSAN/CELLULOSE SCAFFOLD FOR SKIN TISSUE ENGINEERING.
Typ
abstrakt
Jazyk
angličtina
Originální abstrakt
The main objective of the study is to enhance the biomechanical properties and stability of porous chitosan/cellulose scaffolds in a simple one-step fabrication process without any additional crosslinking agents. We investigated the stability of manufactured scaffolds in medium and biocompatibility to verify their degradation time and effect of the degradation product on cells. In the presented study, the effect of glycerol on the chitosan (Chit) scaffold mixed with either oxidized cellulose (Chit/OC), or carboxymethyl cellulose (Chit/CMC) was evaluated. Incorporation of glycerol into porous structures has shown a significant enhancement of viscoelastic properties. The elasticity of the material was 5-fold higher under dry conditions, while the strength of the material grew approximately 20-fold under hydrated conditions. The addition of glycerol significantly improved the enzymatic stability of the scaffolds and the stability in cell culture medium. Four times greater stability has been shown mainly for the Chit/CMC scaffold supplemented with glycerol, while it also reduced the amount of released degradation products, continuously measured over 21 days in enzymatic medium. Glycerol supplementation into porous scaffold could eliminate the utility of commonly used crosslinking agents. Furthermore, glycerol created a more hydrophobic character in the material and lowered swelling properties, while the porosity and pore sizes were not significantly influenced.
Klíčová slova
wound healing, chitosan, cellulose, glycerol
Autoři
VERČIMÁKOVÁ, K.; KARBOWNICZEK, J.; STACHEWICZ, U.; VOJTOVÁ, L.
Vydáno
12. 10. 2023
Nakladatel
Polish Society for Biomaterials, Scientific Publishing House „Akapit”
Místo
Krakow
Strany od
97
Strany do
Strany počet
121
URL
http://biomat.krakow.pl/files/konferencje/rytro/rytro_2023_conference_proceedings.pdf
BibTex
@misc{BUT185713, author="Katarína {Verčimáková} and Joanna {Karbowniczek} and Urszula {Stachewicz} and Lucy {Vojtová}", title="BIOMECHANICAL AND STRUCTURAL EVALUATION OF THE EFFECT OF GLYCEROL ON A RESORABLE CHITOSAN/CELLULOSE SCAFFOLD FOR SKIN TISSUE ENGINEERING.", year="2023", pages="121", publisher="Polish Society for Biomaterials, Scientific Publishing House „Akapit”", address="Krakow", url="http://biomat.krakow.pl/files/konferencje/rytro/rytro_2023_conference_proceedings.pdf", note="abstract" }