Detail publikace

Liposomes Affect Protein Release and Stability of ITA-Modified PLGA-PEG-PLGA Hydrogel Carriers for Controlled Drug Delivery

KADLECOVÁ, Z. SEVRIUGINA, V. LYSÁKOVÁ, K. RYCHETSKÝ, M. CHAMRADOVÁ, I. VOJTOVÁ, L.

Originální název

Liposomes Affect Protein Release and Stability of ITA-Modified PLGA-PEG-PLGA Hydrogel Carriers for Controlled Drug Delivery

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Fat grafting, a key regenerative medicine technique, often requires repeat procedures due to high-fat reabsorption and volume loss. Addressing this, a novel drug delivery system uniquely combines a thermosensitive, FDA-approved hydrogel (itaconic acid-modified PLGA-PEG-PLGA copolymer) with FGF2-STAB, a stable fibroblast growth factor 2 with a 21-day stability, far exceeding a few hours of wild-type FGF2's stability. Additionally, the growth factor was encapsulated in "green" liposomes prepared via the Mozafari method, ensuring pH protection. The system, characterized by first-order FGF2-STAB release, employs green chemistry for biocompatibility, bioactivity, and eco-friendliness. The liposomes, with diameters of 85.73 +/- 3.85 nm and 68.6 +/- 2.2% encapsulation efficiency, allowed controlled FGF2-STAB release from the hydrogel compared to the unencapsulated FGF2-STAB. Yet, the protein compromised the carrier's hydrolytic stability. Prior tests were conducted on model proteins human albumin (efficiency 80.8 +/- 3.2%) and lysozyme (efficiency 81.0 +/- 2.7%). This injectable thermosensitive system could advance reconstructive medicine and cosmetic procedures.

Klíčová slova

Drug delivery, PLGA-PEG-PLGA copolymer, itaconic acid, FGF2-STAB®, Mozafari method, liposomes

Autoři

KADLECOVÁ, Z.; SEVRIUGINA, V.; LYSÁKOVÁ, K.; RYCHETSKÝ, M.; CHAMRADOVÁ, I.; VOJTOVÁ, L.

Vydáno

22. 12. 2023

Nakladatel

AMER CHEMICAL SOC

Místo

WASHINGTON

ISSN

1525-7797

Periodikum

BIOMACROMOLECULES

Ročník

25

Číslo

1

Stát

Spojené státy americké

Strany od

67

Strany do

76

Strany počet

10

URL

https://pubs.acs.org/doi/epdf/10.1021/acs.biomac.3c00736

Plný text v Digitální knihovně

http://hdl.handle.net/11012/245202

BibTex

@article{BUT187107,
  author="Zuzana {Kadlecová} and Veronika {Sevriugina} and Klára {Tušlová} and Matěj {Rychetský} and Ivana {Chamradová} and Lucy {Vojtová}",
  title="Liposomes Affect Protein Release and Stability of ITA-Modified PLGA-PEG-PLGA Hydrogel Carriers for Controlled Drug Delivery",
  journal="BIOMACROMOLECULES",
  year="2023",
  volume="25",
  number="1",
  pages="67--76",
  doi="10.1021/acs.biomac.3c00736",
  issn="1525-7797",
  url="https://pubs.acs.org/doi/epdf/10.1021/acs.biomac.3c00736"
}