Detail publikace

Comprehensive experimental and numerical validation of Lattice Boltzmann fluid flow and particle simulations in a child respiratory tract

PRINZ, F. POKORNÝ, J. ELCNER, J. LÍZAL, F. MIŠÍK, O. MALÝ, M. BĚLKA, M.HAFEN N KUMMERLÄNDER A. KRAUSE M. JEDELSKÝ, J. JÍCHA, M.

Originální název

Comprehensive experimental and numerical validation of Lattice Boltzmann fluid flow and particle simulations in a child respiratory tract

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

The numerical simulation of inhaled aerosols in medical research starts to play a crucial role in understanding local deposition within the respiratory tract, a feat often unattainable experimentally. Research on children is particularly challenging due to the limited availability of in vivo data and the inherent morphological intricacies. CFD solvers based on Finite Volume Methods (FVM) have been widely employed to solve the flow field in such studies. Recently, Lattice Boltzmann Methods (LBM), a mesoscopic approach, have gained prominence, especially for their scalability on High-Performance Computers. This study endeavours to compare the effectiveness of LBM and FVM in simulating particulate flows within a child’s respiratory tract, supporting research related to particle deposition and medication delivery using LBM. Considering a 5-year-old child’s airway model at a steady inspiratory flow, the results are compared with in vitro experiments. Notably, both LBM and FVM exhibit favourable agreement with experimental data for the mean velocity field and the turbulence intensity. For particle deposition, both numerical methods yield comparable results, aligning well with in vitro experiments across a particle size range of 0.1–20 µm. Discrepancies are identified in the upper airways and trachea, indicating a lower deposition fraction than in the experiment. Nonetheless, both LBM and FVM offer invaluable insights into particle behaviour for different sizes, which are not easily achievable experimentally. In terms of practical implications, the findings of this study hold significance for respiratory medicine and drug delivery systems — potential health impacts, targeted drug delivery strategies or optimisation of respiratory therapies.

Klíčová slova

Lattice Boltzmann Method; Finite Volume Method; Particle deposition; In vitro measurement; Child airways

Autoři

PRINZ, F.; POKORNÝ, J.; ELCNER, J.; LÍZAL, F.; MIŠÍK, O.; MALÝ, M.; BĚLKA, M.;HAFEN N; KUMMERLÄNDER A.; KRAUSE M.; JEDELSKÝ, J.; JÍCHA, M.;

Vydáno

1. 3. 2024

ISSN

0010-4825

Periodikum

COMPUTERS IN BIOLOGY AND MEDICINE

Ročník

170

Číslo

107994

Stát

Spojené státy americké

Strany počet

17

URL

https://www.sciencedirect.com/science/article/pii/S0010482524000787?dgcid=author#GS3

BibTex

@article{BUT187750,
  author="PRINZ, F. and POKORNÝ, J. and ELCNER, J. and LÍZAL, F. and MIŠÍK, O. and MALÝ, M. and BĚLKA, M. and HAFEN N and KUMMERLÄNDER A. and KRAUSE M. and JEDELSKÝ, J. and JÍCHA, M.",
  title="Comprehensive experimental and numerical validation of Lattice Boltzmann fluid flow and particle simulations in a child respiratory tract",
  journal="COMPUTERS IN BIOLOGY AND MEDICINE",
  year="2024",
  volume="170",
  number="107994",
  pages="17",
  doi="10.1016/j.compbiomed.2024.107994",
  issn="0010-4825",
  url="https://www.sciencedirect.com/science/article/pii/S0010482524000787?dgcid=author#GS3"
}