Detail publikace

Extracellular Vesicles and Hydrogels: An Innovative Approach to Tissue Regeneration

HASHEMI, A. EZATI, M. PARTOVI NASR, M. ZUMBERG, I. PROVAZNÍK, V.

Originální název

Extracellular Vesicles and Hydrogels: An Innovative Approach to Tissue Regeneration

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Extracellular vesicles have emerged as promising tools in regenerative medicine due to their inherent ability to facilitate intercellular communication and modulate cellular functions. These nanosized vesicles transport bioactive molecules, such as proteins, lipids, and nucleic acids, which can affect the behavior of recipient cells and promote tissue regeneration. However, the therapeutic application of these vesicles is frequently constrained by their rapid clearance from the body and inability to maintain a sustained presence at the injury site. In order to overcome these obstacles, hydrogels have been used as extracellular vesicle delivery vehicles, providing a localized and controlled release system that improves their therapeutic efficacy. This Review will examine the role of extracellular vesicle-loaded hydrogels in tissue regeneration, discussing potential applications, current challenges, and future directions. We will investigate the origins, composition, and characterization techniques of extracellular vesicles, focusing on recent advances in exosome profiling and the role of machine learning in this field. In addition, we will investigate the properties of hydrogels that make them ideal extracellular vesicle carriers. Recent studies utilizing this combination for tissue regeneration will be highlighted, providing a comprehensive overview of the current research landscape and potential future directions.

Klíčová slova

Extracellular vesicles, hydrogels, controlled release, tissue regeneration, machine learning, biofabrication, biocompatibility, and regenerative medicine.

Autoři

HASHEMI, A.; EZATI, M.; PARTOVI NASR, M.; ZUMBERG, I.; PROVAZNÍK, V.

Vydáno

31. 1. 2024

Nakladatel

American Chemical Society

Místo

Washington, USA

ISSN

2470-1343

Periodikum

ACS OMEGA

Ročník

9

Číslo

6

Stát

Spojené státy americké

Strany od

6184

Strany do

6218

Strany počet

35

URL

https://pubs.acs.org/doi/full/10.1021/acsomega.3c08280

Plný text v Digitální knihovně

http://hdl.handle.net/11012/245489

BibTex

@article{BUT188186,
  author="Amir {Hashemi} and Masoumeh {Ezati} and Minoo {Partovi Nasr} and Inna {Zumberg} and Valentine {Provazník}",
  title="Extracellular Vesicles and Hydrogels: An Innovative Approach to Tissue Regeneration",
  journal="ACS OMEGA",
  year="2024",
  volume="9",
  number="6",
  pages="6184--6218",
  doi="10.1021/acsomega.3c08280",
  issn="2470-1343",
  url="https://pubs.acs.org/doi/full/10.1021/acsomega.3c08280"
}