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DOBROVOLNÁ, M. ŠISLEROVÁ, L. BRÁZDA, V. BARTAS, M. ČERVEŇ, J. VALKOVÁ, N. VOLNÁ, A. BALDVINSSON, H. PEČINKA, P.
Originální název
RNA analysis of the longest living vertebrate Greenland shark revealed an abundance of LINE-like elements in its transcriptome
Typ
článek v časopise ve Web of Science, Jimp
Jazyk
angličtina
Originální abstrakt
The Greenland shark (Somniosus microcephalus) is an enigmatic species known for its exceptional longevity and extraordinary adaptations to the cold environment. This animal lives in the arctic and subarctic regions of the North Atlantic Ocean. Surprisingly, even though it is a vertebrate with the longest known lifespan, its transcriptome has not been studied yet. Therefore, we isolated and analyzed RNA in the Greenland shark samples. Our findings reveal some important information about the possible genetic mechanisms that could contribute to its longevity. We identified a highly expressed long interspersed nuclear element-like transcript (LINE-like) that is supposed to be associated with extended lifespan and resilience to age-related diseases, possibly through an improved telomere maintenance mechanism. This research not only contributes to our understanding of the biology and evolution of the Greenland shark but could also have implications for human longevity research.
Klíčová slova
Greenland shark; transcriptome; bioinformatics; LINE -1; longevity research; Somniosus microcephalus
Autoři
DOBROVOLNÁ, M.; ŠISLEROVÁ, L.; BRÁZDA, V.; BARTAS, M.; ČERVEŇ, J.; VALKOVÁ, N.; VOLNÁ, A.; BALDVINSSON, H.; PEČINKA, P.;
Vydáno
1. 3. 2024
Nakladatel
MASARYK UNIV PRESS
Místo
Brno
ISSN
1805-0689
Periodikum
Czech Polar Reports
Ročník
13
Číslo
2
Stát
Česká republika
Strany od
210
Strany do
227
Strany počet
18
URL
https://www.researchgate.net/publication/379016677_RNA_analysis_of_the_longest_living_vertebrate_Greenland_shark_revealed_an_abundance_of_LINE-like_elements_in_its_transcriptome
BibTex
@article{BUT188984, author="DOBROVOLNÁ, M. and ŠISLEROVÁ, L. and BRÁZDA, V. and BARTAS, M. and ČERVEŇ, J. and VALKOVÁ, N. and VOLNÁ, A. and BALDVINSSON, H. and PEČINKA, P.", title="RNA analysis of the longest living vertebrate Greenland shark revealed an abundance of LINE-like elements in its transcriptome", journal="Czech Polar Reports", year="2024", volume="13", number="2", pages="210--227", doi="10.5817/CPR2023-2-17", issn="1805-0689", url="https://www.researchgate.net/publication/379016677_RNA_analysis_of_the_longest_living_vertebrate_Greenland_shark_revealed_an_abundance_of_LINE-like_elements_in_its_transcriptome" }