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KOPŘIVOVÁ, H. KISS, K. KRBAL, L. STEJSKAL, V. BUDAY, J. POŘÍZKA, P. KAŠKA, M. RYŠKA, A. KAISER, J.
Originální název
Imaging the elemental distribution within human malignant melanomas using Laser-Induced Breakdown Spectroscopy
Typ
článek v časopise ve Web of Science, Jimp
Jazyk
angličtina
Originální abstrakt
The diagnosis of malignant melanoma, often an inconspicuous but highly aggressive tumor, is most commonly done by histological examination, while additional diagnostic methods on the level of elements and molecules are constantly being developed. Several studies confirmed differences in the chemical composition of healthy and tumor tissue. Our study presents the potential of the LIBS (Laser -Induced -Breakdown Spectroscopy) technique as a diagnostic tool in malignant melanoma (MM) based on the quantitative changes in elemental composition in cancerous tissue. Our patient group included 17 samples of various types of malignant melanoma and one sample of healthy skin tissue as a control. To achieve a clear perception of results, we have selected two biogenic elements (calcium and magnesium), which showed a dissimilar distribution in cancerous tissue from its healthy surroundings. Moreover, we observed indications of different concentrations of these elements in different subtypes of malignant melanoma, a hypothesis that requires confirmation in a more extensive sample set. The information provided by the LIBS Imaging method could potentially be helpful not only in the diagnostics of tumor tissue but also be beneficial in broadening the knowledge about the tumor itself.
Klíčová slova
Cutaneous cancer; Skin tumor; Diagnostics; Digital histopathology; Chemical analysis; Optical emission spectroscopy
Autoři
KOPŘIVOVÁ, H.; KISS, K.; KRBAL, L.; STEJSKAL, V.; BUDAY, J.; POŘÍZKA, P.; KAŠKA, M.; RYŠKA, A.; KAISER, J.
Vydáno
29. 6. 2024
Nakladatel
Elsevier
Místo
AMSTERDAM
ISSN
1873-4324
Periodikum
Analytica Chimica Acta
Ročník
1310
Číslo
6
Stát
Nizozemsko
Strany od
1
Strany do
8
Strany počet
URL
https://www.sciencedirect.com/science/article/pii/S0003267024004641
Plný text v Digitální knihovně
http://hdl.handle.net/11012/249393
BibTex
@article{BUT189156, author="Hana {Kopřivová} and Kateřina {Kiss} and Lukáš {Krbal} and Václav {Stejskal} and Jakub {Buday} and Pavel {Pořízka} and Milan {Kaška} and Aleš {Ryška} and Jozef {Kaiser}", title="Imaging the elemental distribution within human malignant melanomas using Laser-Induced Breakdown Spectroscopy", journal="Analytica Chimica Acta", year="2024", volume="1310", number="6", pages="8", doi="10.1016/j.aca.2024.342663", issn="1873-4324", url="https://www.sciencedirect.com/science/article/pii/S0003267024004641" }