Detail publikace

Choosing the right electrode representation for modeling real bioelectronic interfaces: a comprehensive guide

OPANČAR, A. GLOWACKI, E. DEREK, V.

Originální název

Choosing the right electrode representation for modeling real bioelectronic interfaces: a comprehensive guide

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Objective. Producing realistic numerical models of neurostimulation electrodes in contact with the electrolyte and tissue, for use in time-domain finite element method simulations while maintaining a reasonable computational burden remains a challenge. We aim to provide a straightforward experimental-theoretical hybrid approach for common electrode materials (Ti, TiN, ITO, Au, Pt, IrOx) that are relevant to the research field of bioelectronics, along with all the information necessary to replicate our approach in arbitrary geometry for real-life experimental applications. Approach. We used electrochemical impedance spectroscopy (EIS) to extract the electrode parameters in the AC regime under different DC biases. The pulsed electrode response was obtained by fast amperometry (FA) to optimize and verify the previously obtained electrode parameters in a COMSOL Multiphysics model. For optimization of the electrode parameters a constant phase element (CPE) needed to be implemented in time-domain. Main results. We find that the parameters obtained by EIS can be used to accurately simulate pulsed response only close to the electrode open circuit potential, while at other potentials we give corrections to the obtained parameters, based on FA measurements. We also find that for many electrodes (Au, TiN, Pt, and IrOx), it is important to implement a distributed CPE rather than an ideal capacitor for estimating the electrode double-layer capacitance. We outline and provide examples for the novel time-domain implementation of the CPE for finite element method simulations in COMSOL Multiphysics. Significance. An overview of electrode parameters for some common electrode materials can be a valuable and useful tool in numerical bioelectronics models. A provided FEM implementation model can be readily adapted to arbitrary electrode geometries and used for various applications. Finally, the presented methodology for parametrization of electrode materials can be used for any materials of interest which were not covered by this work.

Klíčová slova

bioelectronics; electrodes; interface; constant phase element; simulation

Autoři

OPANČAR, A.; GLOWACKI, E.; DEREK, V.

Vydáno

1. 8. 2024

Nakladatel

IOP Publishing

Místo

BRISTOL

ISSN

1741-2560

Periodikum

J NEURAL ENG

Ročník

21

Číslo

4

Stát

Spojené království Velké Británie a Severního Irska

Strany od

1

Strany do

17

Strany počet

17

URL

https://iopscience.iop.org/article/10.1088/1741-2552/ad6a8b

Plný text v Digitální knihovně

http://hdl.handle.net/11012/250184

BibTex

@article{BUT189841,
  author="Aleksandar {Opančar} and Eric Daniel {Glowacki} and Vedran {Derek}",
  title="Choosing the right electrode representation for modeling real bioelectronic interfaces: a comprehensive guide",
  journal="J NEURAL ENG",
  year="2024",
  volume="21",
  number="4",
  pages="17",
  doi="10.1088/1741-2552/ad6a8b",
  issn="1741-2560",
  url="https://iopscience.iop.org/article/10.1088/1741-2552/ad6a8b"
}