Detail publikace

Improving the processability and mechanical strength of self-hardening robocasted hydroxyapatite scaffolds with silane coupling agents

PANTAK, P CZECHOWSKA, J KASHIMBETOVA, A. ČELKO, L. MONTUFAR JIMENEZ, E. WÓJCIK, L. ZIMA, A.

Originální název

Improving the processability and mechanical strength of self-hardening robocasted hydroxyapatite scaffolds with silane coupling agents

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Bone cements are the subject of intensive research, primarily due to their versatility and the increasing importance for personalized medicine. In this study, novel hybrid self-setting scaffolds, based on calcium phosphates and natural polymers, were fabricated using the robocasting technique. Additionally, the influence of two different silane coupling agents, tetraethyl orthosilicate (TEOS) and 3-glycidoxypropyltrimethoxysilane (GPTMS), on the physicochemical and biological properties of the obtained materials was thoroughly investigated. The chemical and phase compositions (XRF, XRD, FTIR), setting process, rheological properties, mechanical strength, microstructure (SEM), and chemical stability in vitro were comprehensively examined. The use of silane coupling agents improved compressive strength of the scaffolds from 5.20 to 9.26 MPa. The incorporation of citrus pectin into the liquid phase of the materials, along with the use of a hybrid hydroxyapatitechitosan powder, not only facilitated the development of printable pastes suitable for robocasting but also enhanced the physicochemical properties of the robocasted scaffolds. The results presented in this study underscore the beneficial influence of silane coupling agents on the characteristics of calcium phosphate-based bone scaffolds. Developed robocasted scaffolds hold great potential for applications in the field of bone tissue engineering and personalized medicine. Further in vitro and in vivo studies are necessary to validate their suitability for clinical applications.

Klíčová slova

alpha-TCP; Biopolymers; Silane coupling agents; Hybrid materials; 3d printing; Robocasting

Autoři

PANTAK, P; CZECHOWSKA, J; KASHIMBETOVA, A.; ČELKO, L.; MONTUFAR JIMENEZ, E.; WÓJCIK, L.; ZIMA, A.

Vydáno

1. 1. 2025

Nakladatel

ELSEVIER

Místo

AMSTERDAM

ISSN

1751-6161

Periodikum

Journal of the mechanical behavior of biomedical materials

Ročník

161

Číslo

106792

Stát

Nizozemsko

Strany počet

11

URL

https://www.webofscience.com/wos/woscc/full-record/WOS:001359363900001

BibTex

@article{BUT193668,
  author="PANTAK, P and CZECHOWSKA, J and KASHIMBETOVA, A. and ČELKO, L. and MONTUFAR JIMENEZ, E. and WÓJCIK, L. and ZIMA, A.",
  title="Improving the processability and mechanical strength of self-hardening robocasted hydroxyapatite scaffolds with silane coupling agents",
  journal="Journal of the mechanical behavior of biomedical materials",
  year="2025",
  volume="161",
  number="106792",
  pages="11",
  doi="10.1016/j.jmbbm.2024.106792",
  issn="1751-6161",
  url="https://www.webofscience.com/wos/woscc/full-record/WOS:001359363900001"
}