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FIALOVÁ, K. KOLÁŘOVÁ, J. SEKORA, J. TANNENBERG, M. NOVÁKOVÁ, M. PROVAZNÍK, I.
Originální název
Electrophysiological effects of Voltage-Sensitive Dye di-4-ANEPPS in Rabbit and Guinea Pig Isolated Heart
Typ
článek ve sborníku ve WoS nebo Scopus
Jazyk
angličtina
Originální abstrakt
Voltage-sensitive dye (VSD) di-4-ANEPPS is currently used in our laboratory for recording of monophasic action potentials (MAPs) in isolated hearts. In this study, its electrophysiological effects on rabbit and guinea pig myocardium were compared during staining with VSD and washout from it. Electrograms were recorded and heart rate changes and the types and frequency of arrhythmias were evaluated. Althought certain electrophysiological changes were present in the hearts of both species, these changes are mostly reversible, especially in rabbit hearts. Thus, rabbit myocardium can be considered a reliable model for electrophysiological studies, especially when generation and propagation of the impulse is studied. It may be concluded that rabbit isolated heart is more suitable model for electrophysiological studies in the isolated heart model than guinea pig heart.
Klíčová slova
Voltage-sensitive dye (VSD) di-4-ANEPPS, electrogram
Autoři
FIALOVÁ, K.; KOLÁŘOVÁ, J.; SEKORA, J.; TANNENBERG, M.; NOVÁKOVÁ, M.; PROVAZNÍK, I.
Rok RIV
2010
Vydáno
30. 6. 2010
Nakladatel
Brno University of Technology
Místo
Brno
ISBN
978-80-214-4106-4
Kniha
Proceedings of Biosignal 2010: Analysis of Biomedical Signals and Images
Číslo edice
20
Strany od
108
Strany do
113
Strany počet
6
BibTex
@inproceedings{BUT35735, author="Kateřina {Fialová} and Jana {Kolářová} and Jiří {Sekora} and Milan {Tannenberg} and Marie {Nováková} and Valentine {Provazník}", title="Electrophysiological effects of Voltage-Sensitive Dye di-4-ANEPPS in Rabbit and Guinea Pig Isolated Heart", booktitle="Proceedings of Biosignal 2010: Analysis of Biomedical Signals and Images", year="2010", number="20", pages="108--113", publisher="Brno University of Technology", address="Brno", isbn="978-80-214-4106-4" }