Detail publikace

Prefrontal but not temporal gray matter changes in males with first-episode schizophrenia

KAŠPÁREK, T. PŘIKRYL, R. MIKL, M. SCHWARZ, D. ČEŠKOVÁ, E. KRUPA, P.

Originální název

Prefrontal but not temporal gray matter changes in males with first-episode schizophrenia

Typ

článek v časopise - ostatní, Jost

Jazyk

angličtina

Originální abstrakt

Objectives of the study was to investigate regional gray matter changes in the first-episode schizophrenia patients. We used optimized voxel-based morphometry in 22 first-episode schizophrenia patients and 18 healthy controls of comparable age, gender and handedness. The first episode group had significantly reduced gray matter volume in the prefrontal cortex (inferior and middle prefrontal gyrus, cingulate gyrus). We identified no differences in temporal cortex. Our data support the theoretical assumption that prefrontal dysfunction underlines the primary pathology and clinical manifestation of schizophrenia. We are inclined to explain the differences in the pattern of morphological changes reported in other first-episode studies - especially the lack of changes in the temporal cortex - by heterogenity of schizophrenia, potential progression and antipsychotic medication effect.

Klíčová slova

first-episode; optimized voxel-based morphometry; prefrontal cortex; schizophrenia

Autoři

KAŠPÁREK, T.; PŘIKRYL, R.; MIKL, M.; SCHWARZ, D.; ČEŠKOVÁ, E.; KRUPA, P.

Vydáno

1. 1. 2007

Nakladatel

Elsevier

ISSN

0278-5846

Periodikum

Progress In Neuro-Psychopharmacology & Biological Psychiatry

Ročník

2007

Číslo

31

Stát

Spojené království Velké Británie a Severního Irska

Strany od

151

Strany do

157

Strany počet

7

BibTex

@article{BUT43824,
  author="Tomáš {Kašpárek} and Radovan {Přikryl} and Michal {Mikl} and Daniel {Schwarz} and Eva {Češková} and Petr {Krupa}",
  title="Prefrontal but not temporal gray matter changes in males with first-episode schizophrenia",
  journal="Progress In Neuro-Psychopharmacology & Biological Psychiatry",
  year="2007",
  volume="2007",
  number="31",
  pages="151--157",
  issn="0278-5846"
}