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KAŠPÁREK, T. PŘIKRYL, R. MIKL, M. SCHWARZ, D. ČEŠKOVÁ, E. KRUPA, P.
Originální název
Prefrontal but not temporal gray matter changes in males with first-episode schizophrenia
Typ
článek v časopise - ostatní, Jost
Jazyk
angličtina
Originální abstrakt
Objectives of the study was to investigate regional gray matter changes in the first-episode schizophrenia patients. We used optimized voxel-based morphometry in 22 first-episode schizophrenia patients and 18 healthy controls of comparable age, gender and handedness. The first episode group had significantly reduced gray matter volume in the prefrontal cortex (inferior and middle prefrontal gyrus, cingulate gyrus). We identified no differences in temporal cortex. Our data support the theoretical assumption that prefrontal dysfunction underlines the primary pathology and clinical manifestation of schizophrenia. We are inclined to explain the differences in the pattern of morphological changes reported in other first-episode studies - especially the lack of changes in the temporal cortex - by heterogenity of schizophrenia, potential progression and antipsychotic medication effect.
Klíčová slova
first-episode; optimized voxel-based morphometry; prefrontal cortex; schizophrenia
Autoři
KAŠPÁREK, T.; PŘIKRYL, R.; MIKL, M.; SCHWARZ, D.; ČEŠKOVÁ, E.; KRUPA, P.
Vydáno
1. 1. 2007
Nakladatel
Elsevier
ISSN
0278-5846
Periodikum
Progress In Neuro-Psychopharmacology & Biological Psychiatry
Ročník
2007
Číslo
31
Stát
Spojené království Velké Británie a Severního Irska
Strany od
151
Strany do
157
Strany počet
7
BibTex
@article{BUT43824, author="Tomáš {Kašpárek} and Radovan {Přikryl} and Michal {Mikl} and Daniel {Schwarz} and Eva {Češková} and Petr {Krupa}", title="Prefrontal but not temporal gray matter changes in males with first-episode schizophrenia", journal="Progress In Neuro-Psychopharmacology & Biological Psychiatry", year="2007", volume="2007", number="31", pages="151--157", issn="0278-5846" }