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KŘÍŽKOVÁ, S. ZÍTKA, O. MASAŘÍK, M. ADAM, V. STIBOROVÁ, M. ECKSCHLAGER, T. GRACE, C. KIZEK, R.
Originální název
Assays for determination of matrix metalloproteinases and their activity
Typ
článek v časopise ve Web of Science, Jimp
Jazyk
angličtina
Originální abstrakt
Matrix metalloproteinases (MMPs) are involved in many physiological and pathological processes. Due to their ability to cleave and to remodel components of surrounding tissues, MMPs may affect cell migration, differentiation, growth, inflammatory processes, neovascularization, wound healing, apoptosis, the uterine cycle and many other actions within the body, including those needed for tumorigenesis and other diseases. MMPs can therefore be used as potential markers for detecting various cancers, neurodegenerative, and immune and cardiovascular diseases. Numerous MMP assays were developed for clinical and research purposes, but far more attention has been devoted to understanding their biological functions. Due to differences in methodology, results obtained in various laboratory settings are difficult to compare because of the lack of standards and analyticalmethods of validation. Limits of detection of particularmethods used for identifyingMMPs are also disputable. Enzymatic, immunochemical and fluorimetric methods are particularly suitable for clinical use. In-vivo imaging methods offer many potential advantages in cancer research and diagnostics. Other methods are subject to investigation
Klíčová slova
matalloproteinase, pathological process
Autoři
KŘÍŽKOVÁ, S.; ZÍTKA, O.; MASAŘÍK, M.; ADAM, V.; STIBOROVÁ, M.; ECKSCHLAGER, T.; GRACE, C.; KIZEK, R.
Rok RIV
2011
Vydáno
1. 12. 2011
ISSN
0165-9936
Periodikum
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Ročník
2011 (30)
Číslo
10
Stát
Spojené království Velké Británie a Severního Irska
Strany od
1819
Strany do
1832
Strany počet
14
BibTex
@article{BUT75727, author="Soňa {Křížková} and Ondřej {Zítka} and Michal {Masařík} and Vojtěch {Adam} and Marie {Stiborová} and Tomáš {Eckschlager} and Chavis J. {Grace} and René {Kizek}", title="Assays for determination of matrix metalloproteinases and their activity", journal="TRAC-TRENDS IN ANALYTICAL CHEMISTRY", year="2011", volume="2011 (30)", number="10", pages="1819--1832", doi="10.1016/j.trac.2011.06.016", issn="0165-9936" }