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VACULOVIČOVÁ, M. HYNEK, D. ŠKUTKOVÁ, H. ADAM, V. PROVAZNÍK, I. KIZEK, R.
Originální název
Structural changes in metallothionein isoforms revealed by capillary electrophoresis and Brdicka reaction
Typ
článek v časopise ve Web of Science, Jimp
Jazyk
angličtina
Originální abstrakt
Metallothionein (MT) as a potential cancer marker is at the center of interest and its properties, function and behaviour under various condititons is intensively studied. In the present study, two major mammalian MT isoforms (MT-1 and MT-2) were separated using capillary electrophoresis (CE) coupled with UV detector in order to describe their basic behavior. The results were confirmed by manual spectrometric measurements and by different pulse voltammetry Brdicka reaction. Based on these results, a model of MT behaviour under the conditions studied was suggested.
Klíčová slova
Brdicka reaction; Cancer; CE; Denaturation; Electrochemistry; Isoforms; Metallothionein
Autoři
VACULOVIČOVÁ, M.; HYNEK, D.; ŠKUTKOVÁ, H.; ADAM, V.; PROVAZNÍK, I.; KIZEK, R.
Rok RIV
2012
Vydáno
1. 1. 2012
ISSN
0173-0835
Periodikum
Electrophoresis
Ročník
33
Číslo
2
Stát
Spolková republika Německo
Strany od
270
Strany do
279
Strany počet
10
BibTex
@article{BUT90347, author="Markéta {Vaculovičová} and David {Hynek} and Helena {Vítková} and Vojtěch {Adam} and Valentine {Provazník} and René {Kizek}", title="Structural changes in metallothionein isoforms revealed by capillary electrophoresis and Brdicka reaction", journal="Electrophoresis", year="2012", volume="33", number="2", pages="270--279", doi="10.1002/elps.201100312", issn="0173-0835" }