Detail publikace

Effect of selenium in organic and inorganic form on liver, kidney, brain and muscle from Wistar rats

SOCHOR, J. POHANKA, M. RUTTKAY-NEDECKÝ, B. ZÍTKA, O. HYNEK, D. MAREŠ, P. ZEMAN, L. ADAM, V. KIZEK, R.

Originální název

Effect of selenium in organic and inorganic form on liver, kidney, brain and muscle from Wistar rats

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Selenium is a micronutrient, localized in the active sites of enzymes such as glutathione peroxidase and thioredoxin reductase, and participating together with these enzymes in an antioxidant defence system of organisms against free radicals. Administration of selenium is necessary for maintaining oxidative homeostasis. The present experiment is aimed at investigation of selenium impact on basal metabolic processes and selected antioxidants in a Wistar rat model, fed selenium in organic and inorganic forms. Liver, kidney, brain and muscle were sampled during a month-long feeding with four different doses of selenium (0.075 mg or 1.5 mg of inorganic and/or organic selenium per kg of feed). We found a significant reduction in glutathione level in liver tissue regardless of the form of the administered selenium. On the other hand, selenium caused a decreased glutathione reductase level in the liver and metallothionein level in the liver, kidney and muscle.

Klíčová slova

Selenium; Oxidative Stress; Glutathione; Glutathione Reductase; Metallothionein

Autoři

SOCHOR, J.; POHANKA, M.; RUTTKAY-NEDECKÝ, B.; ZÍTKA, O.; HYNEK, D.; MAREŠ, P.; ZEMAN, L.; ADAM, V.; KIZEK, R.

Rok RIV

2012

Vydáno

1. 10. 2012

Nakladatel

VERSITA, SOLIPSKA 14A-1, 02-482

Místo

WARSAW, POLAND

ISSN

1895-1066

Periodikum

CENTRAL EUROPEAN JOURNAL OF CHEMISTRY

Ročník

10

Číslo

5

Stát

Polská republika

Strany od

1442

Strany do

1451

Strany počet

9

BibTex

@article{BUT98607,
  author="SOCHOR, J. and POHANKA, M. and RUTTKAY-NEDECKÝ, B. and ZÍTKA, O. and HYNEK, D. and MAREŠ, P. and ZEMAN, L. and ADAM, V. and KIZEK, R.",
  title="Effect of selenium in organic and inorganic form on liver, kidney, brain and muscle from Wistar rats",
  journal="CENTRAL EUROPEAN JOURNAL OF CHEMISTRY",
  year="2012",
  volume="10",
  number="5",
  pages="1442--1451",
  issn="1895-1066"
}