Detail publikace

Influence of pulsed electromagnetic and pulsed vector magnetic potential field on the growth of tumor cells

LOJA, T. STEHLÍKOVÁ, O. PALKO, L. VRBA, K. RAMPL, I. KLABUSAY, M.

Originální název

Influence of pulsed electromagnetic and pulsed vector magnetic potential field on the growth of tumor cells

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Tumor diseases cause 20% of deaths in Europe and they are the second most common cause of death and morbidity after cardiovascular diseases. Thus, tumor cells are target of many therapeutic strategies and tumor research is focused on searching more efficient and specific drugs as well as new therapeutic approaches. One of the areas of tumor research is an issue of external fields. In our work, we tested influence of a pulsed electromagnetic field (PEMF) and a hypothetic field of the pulsed vector magnetic potential (PVMP) on the growth of tumor cells; and further the possible growth inhibition effect of the PVMP. Methods: Both unipolar and bipolar PEMF fields of 5mT and PVMP fields of 0mT at frequencies of 15 Hz, 125 Hz and 625 Hz were tested on cancer cell lines derived from various types of tumors: CEM/C2 (acute lymphoblastic leukemia), SU-DHL-4 (B-cell lymphoma), COLO-320DM (colorectal adenocarcinoma), MDA-BM-468 (breast adenocarcinoma), and ZR-75-1 (ductal carcinoma). Cell morphology was observed, proliferation activity using WST assay was measured and simultaneous proportion of live, early apoptotic and dead cells was detected using flow cytometry. Results: A PEMF of 125 Hz and 625 Hz for 24 h–48 h increased proliferation activity in the 2 types of cancer cell lines used, i.e. COLO-320DM and ZR-75-1. In contrast, any of employed methods did not confirm a significant inhibitory effect of hypothetic PVMP field on tumor cells.

Klíčová slova

Cancer cell lines, cell viability, pulsed electromagnetic field (PEMF), pulsed vector magnetic potential (PVMP) field, IVMP

Autoři

LOJA, T.; STEHLÍKOVÁ, O.; PALKO, L.; VRBA, K.; RAMPL, I.; KLABUSAY, M.

Rok RIV

2013

Vydáno

10. 6. 2013

Nakladatel

Electromagn Biol Med.

Místo

USA ISSN: 1536-8378 (print), 1536-8386 (electronic)

ISSN

1536-8378

Periodikum

ELECTROMAGNETIC BIOLOGY AND MEDICINE

Ročník

2013

Stát

Spojené státy americké

Strany od

1

Strany do

8

Strany počet

8

URL

http://informahealthcare.com/ebm

BibTex

@article{BUT100209,
  author="Tomáš {Loja} and Olga {Stehlíková} and Lukáš {Palko} and Kamil {Vrba} and Ivan {Rampl} and Martin {Klabusay}",
  title="Influence of pulsed electromagnetic and pulsed vector magnetic potential field on the growth of tumor cells",
  journal="ELECTROMAGNETIC BIOLOGY AND MEDICINE",
  year="2013",
  volume="2013",
  number="0",
  pages="1--8",
  doi="10.3109/15368378.2013.800104",
  issn="1536-8378",
  url="http://informahealthcare.com/ebm"
}