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SCOBIE, L. PADLER-KARAVANI, V. LE BAS-BERNARDET, S. CROSSAN, C. BLAHA, J. MATOUŠKOVÁ, M. HECTOR, R. VANHOVE, B. CHARREAU, B. BLANCHO, G. TALLACCHINI, M. RIBES, J. YU, H. CHEN, X. KRACÍKOVÁ, J. BROŽ, L. HEJNAR, J. VESELÝ, P. TAKEUCHI, Y. VARKI, A. SOULILLOU, J.
Originální název
Long-Term IgG Response to Porcine Neu5Gc Antigens without Transmission of PERV in Burn Patients Treated with Porcine Skin Xenografts
Typ
článek v časopise ve Web of Science, Jimp
Jazyk
angličtina
Originální abstrakt
Acellular materials of xenogenic origin are used worldwide as xenografts, and phase I trials of viable pig pancreatic islets are currently being performed. However, limited information is available on transmission of porcine endogenous retrovirus (PERV) after xenotransplantation and on the long-term immune response of recipients to xenoantigens. We analyzed the blood of burn patients who had received living pig-skin dressings for up to 8 wk for the presence of PERV as well as for the level and nature of their long term (maximum, 34 y) immune response against pig Ags. Although no evidence of PERV genomic material or anti-PERV Ab response was found, we observed a moderate increase in anti-alpha Gal Abs and a high and sustained anti-non-alpha Gal IgG response in those patients. Abs against the nonhuman sialic acid Neu5Gc constituted the anti-non-alpha Gal response with the recognition pattern on a sialoglycan array differing from that of burn patients treated without pig skin. These data suggest that anti-Neu5Gc Abs represent a barrier for long-term acceptance of porcine xenografts. Because anti-Neu5Gc Abs can promote chronic inflammation, the long-term safety of living and acellular pig tissue implants in recipients warrants further evaluation.
Klíčová slova
n-GLYCOLYLNEURAMINIC ACID; HUMAN NATURAL ANTIBODIES; GENE-KNOCKOUT PIGS; NON-GAL ANTIBODIES; ENDOGENOUS RETROVIRUS; SIALIC-ACID; HUMAN XENOTRANSPLANTATION; XENO-AUTOANTIBODIES; NUCLEAR TRANSFER; INFECTION
Autoři
SCOBIE, L.; PADLER-KARAVANI, V.; LE BAS-BERNARDET, S.; CROSSAN, C.; BLAHA, J.; MATOUŠKOVÁ, M.; HECTOR, R.; VANHOVE, B.; CHARREAU, B.; BLANCHO, G.; TALLACCHINI, M.; RIBES, J.; YU, H.; CHEN, X.; KRACÍKOVÁ, J.; BROŽ, L.; HEJNAR, J.; VESELÝ, P.; TAKEUCHI, Y.; VARKI, A.; SOULILLOU, J.
Rok RIV
2013
Vydáno
15. 9. 2013
ISSN
0022-1767
Periodikum
JOURNAL OF IMMUNOLOGY
Ročník
191
Číslo
6
Stát
Spojené státy americké
Strany od
2907
Strany do
2915
Strany počet
9
BibTex
@article{BUT107928, author="Linda {Scobie} and Veren {Padler-Karavani} and Stephanie {Le Bas-Bernardet} and Claire {Crossan} and Josef {Blaha} and Magda {Matoušková} and Ralph D. {Hector} and Bernard {Vanhove} and Beatrice {Charreau} and Gilles {Blancho} and Mariachiara {Tallacchini} and Juan M {Ribes} and Hai {Yu} and Xi {Chen} and Jitka {Kracíková} and Ludomír {Brož} and Jiří {Hejnar} and Pavel {Veselý} and Yasuhiro {Takeuchi} and Ajit {Varki} and Jean-Paul {Soulillou}", title="Long-Term IgG Response to Porcine Neu5Gc Antigens without Transmission of PERV in Burn Patients Treated with Porcine Skin Xenografts", journal="JOURNAL OF IMMUNOLOGY", year="2013", volume="191", number="6", pages="2907--2915", doi="10.4049/jimmunol.1301195", issn="0022-1767" }