Detail publikace

Decision support framework for Parkinsons disease based on novel handwriting markers

DROTÁR, P. MEKYSKA, J. REKTOROVÁ, I. MASAROVÁ, L. SMÉKAL, Z. FAÚNDEZ ZANUY, M.

Originální název

Decision support framework for Parkinsons disease based on novel handwriting markers

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Parkinsons disease (PD) is a neurodegenerative disorder which impairs motor skills, speech, and other functions such as behavior, mood, and cognitive processes. One of the most typical clinical hallmarks of PD is handwriting deterioration, usually the first manifestation of PD. The aim of this study is twofold: (a) to find a subset of handwriting features suitable for identifying subjects with PD and (b) to build a predictive model to efficiently diagnose PD. We collected handwriting samples from 37 medicated PD patients and 38 age- and sex- matched controls. The handwriting samples were collected during seven tasks such as writing a syllable, word, or sentence. Every sample was used to extract the handwriting measures. In addition to conventional kinematic and spatio-temporal handwriting measures, we also computed novel handwriting measures based on entropy, signal energy, and empirical mode decomposition of the handwriting signals. The selected features were fed to the support vector machine classifier with radial Gaussian kernel for automated diagnosis. The accuracy of the classification of PD was as high as 88:13%, with the highest values of sensitivity and specificity equal to 89:47% and 91:89%, respectively. Handwriting may be a valuable marker as a diagnostic and screening tool

Klíčová slova

Parkinsons disease, handwriting, tablet, decision support system, biomarker

Autoři

DROTÁR, P.; MEKYSKA, J.; REKTOROVÁ, I.; MASAROVÁ, L.; SMÉKAL, Z.; FAÚNDEZ ZANUY, M.

Rok RIV

2014

Vydáno

8. 5. 2015

Nakladatel

IEEE

Místo

USA

ISSN

1534-4320

Periodikum

IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING

Ročník

23

Číslo

3

Stát

Spojené státy americké

Strany od

508

Strany do

516

Strany počet

9

BibTex

@article{BUT110178,
  author="Peter {Drotár} and Jiří {Mekyska} and Irena {Rektorová} and Lucia {Masarová} and Zdeněk {Smékal} and Marcos {Faúndez Zanuy}",
  title="Decision support framework for Parkinsons disease based on novel handwriting markers",
  journal="IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING",
  year="2015",
  volume="23",
  number="3",
  pages="508--516",
  doi="10.1109/TNSRE.2014.2359997",
  issn="1534-4320"
}