Detail publikace

Electrochemical Study of Ellipticine Interaction with Single and Double Stranded Oligonucleotides

TMEJOVÁ, K. KREJČOVÁ, L. HYNEK, D. ADAM, V. BABULA, P. TRNKOVÁ, L. STIBOROVÁ, M. ECKSCHLAGER, T. KIZEK, R.

Originální název

Electrochemical Study of Ellipticine Interaction with Single and Double Stranded Oligonucleotides

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Ellipticine (5,11-dimethyl-6H-pyrido[4,3-b]carbazole) is an alkaloid that has been isolated from plants of an Apocynaceae family. It is one of the simplest naturally occurring alkaloids with a planar structure. Over the past decades, ellipticine became a very promising antitumor agent. Interaction with DNA is one of the most studied ellipticine effects on cell division. This phenomenon is not clearly explained so far. In our experiments we studied interaction of ellipticine with single-stranded and double-stranded oligonucleotides by electrochemical methods on mercury electrode. Differential pulse voltammetry was applied for ellipticine (Elli) and CA peak detection. Square wave voltammetry was applied for G peak detection. The effect of the interaction time and ellipticine concentrations on interactions of ellipticine with single- and double-stranded oligonucleotides was tested too.

Klíčová slova

Adsorptive transfer stripping technique, DNA, differential pulse voltammetry, ellipticine, hetero-nucleotides, intercalation, square wave voltammetry, cancer, therapy

Autoři

TMEJOVÁ, K.; KREJČOVÁ, L.; HYNEK, D.; ADAM, V.; BABULA, P.; TRNKOVÁ, L.; STIBOROVÁ, M.; ECKSCHLAGER, T.; KIZEK, R.

Rok RIV

2014

Vydáno

1. 2. 2014

ISSN

1871-5206

Periodikum

Anti-Cancer Agents in Medicinal Chemistry

Ročník

14

Číslo

2

Stát

Stát Spojené arabské emiráty

Strany od

331

Strany do

340

Strany počet

10

BibTex

@article{BUT110907,
  author="Kateřina {Tmejová} and Ludmila {Krejčová} and David {Hynek} and Vojtěch {Adam} and Petr {Babula} and Libuše {Trnková} and Marie {Stiborová} and Tomáš {Eckschlager} and René {Kizek}",
  title="Electrochemical Study of Ellipticine Interaction with Single and Double Stranded Oligonucleotides",
  journal="Anti-Cancer Agents in Medicinal Chemistry",
  year="2014",
  volume="14",
  number="2",
  pages="331--340",
  issn="1871-5206"
}