Detail publikace

A method for in vitro regional aerosol deposition measurement in a model of the human tracheobronchial tree by the positron emission tomography

LÍZAL, F. BĚLKA, M. ADAM, J. JEDELSKÝ, J. JÍCHA, M.

Originální název

A method for in vitro regional aerosol deposition measurement in a model of the human tracheobronchial tree by the positron emission tomography

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

This article introduces a method based on positron emission tomography, which allows acquisition of detailed experimental data on local aerosol deposition in a realistic model of human lungs. The method utilizes the Condensation Monodisperse Aerosol Generator modified for a safe production of radioactive aerosol particles and a special measuring rig. The scanning of the model is performed on a positron emission tomography–computed tomography scanner. The evaluation of aerosol deposition is based on a volume radioactivity analysis in a specialized, yet publicly available software. The reliability of the method was tested and its first results are discussed in the article. The measurements performed using the presented method can serve for validation of numerical simulations, since the presented lung model digital geometry is available.

Klíčová slova

positro emission tomography, aerosol, aerosol deposition, targeted drug delivery

Autoři

LÍZAL, F.; BĚLKA, M.; ADAM, J.; JEDELSKÝ, J.; JÍCHA, M.

Rok RIV

2015

Vydáno

1. 10. 2015

Nakladatel

SAGE Publications

Místo

London, UK

ISSN

0954-4119

Periodikum

PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE

Ročník

229

Číslo

10

Stát

Spojené království Velké Británie a Severního Irska

Strany od

750

Strany do

757

Strany počet

8

BibTex

@article{BUT117312,
  author="František {Lízal} and Miloslav {Bělka} and Jan {Adam} and Jan {Jedelský} and Miroslav {Jícha}",
  title="A method for in vitro regional aerosol deposition measurement in a model of the human tracheobronchial tree by the positron emission tomography",
  journal="PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART H-JOURNAL OF ENGINEERING IN MEDICINE",
  year="2015",
  volume="229",
  number="10",
  pages="750--757",
  doi="10.1177/0954411915600005",
  issn="0954-4119"
}