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Couvrat-Desvergnes, G. Salama, A. Le Berre, L Evanno, G. Viklicky, O. Hruba, P. Vesely, P. Guerif, P Dejoie, T. Rousse, J. Nicot, A. Bach, JM. Ang, E. Foucher, Y. Brouard, S. Castagnet, S. Giral, M. Harb, J. Perreault, H. Charreau, B. Lorent, M. Soulillou, JP
Originální název
Rabbit antithymocyte globulin–induced serum sickness disease and human kidney graft survival
Typ
článek v časopise ve Web of Science, Jimp
Jazyk
angličtina
Originální abstrakt
Rabbit-generated antithymocyte globulins (ATGs), which target human T cells, are widely used as immunosuppressive agents during treatment of kidney allograft recipients. However, ATGs can induce immune complex diseases, including serum sickness disease (SSD). Rabbit and human IgGs have various antigenic differences, including expression of the sialic acid Neu5Gc and α-1-3-Gal (Gal), which are not synthesized by human beings. Moreover, anti-Neu5Gc antibodies have been shown to preexist and be elicited by immunization in human subjects. This study aimed to assess the effect of SSD on long-term kidney allograft outcome and to compare the immunization status of grafted patients presenting with SSD following ATG induction treatment.
Klíčová slova
Rabbit antithymocyte globulin; serum sickness disease
Autoři
Couvrat-Desvergnes, G.; Salama, A.; Le Berre, L; Evanno, G.; Viklicky, O.; Hruba, P.; Vesely, P.; Guerif, P; Dejoie, T.; Rousse, J.; Nicot, A.; Bach, JM. ; Ang, E.; Foucher, Y.; Brouard, S.; Castagnet, S.; Giral, M.; Harb, J.; Perreault, H.; Charreau, B.; Lorent, M.; Soulillou, JP
Rok RIV
2015
Vydáno
1. 12. 2015
ISSN
0021-9738
Periodikum
JOURNAL OF CLINICAL INVESTIGATION
Ročník
125
Číslo
12
Stát
Spojené státy americké
Strany od
4655
Strany do
4665
Strany počet
11
BibTex
@article{BUT120517, author="Couvrat-Desvergnes, G. and Salama, A. and Le Berre, L and Evanno, G. and Viklicky, O. and Hruba, P. and Vesely, P. and Guerif, P and Dejoie, T. and Rousse, J. and Nicot, A. and Bach, JM. and Ang, E. and Foucher, Y. and Brouard, S. and Castagnet, S. and Giral, M. and Harb, J. and Perreault, H. and Charreau, B. and Lorent, M. and Soulillou, JP", title="Rabbit antithymocyte globulin–induced serum sickness disease and human kidney graft survival", journal="JOURNAL OF CLINICAL INVESTIGATION", year="2015", volume="125", number="12", pages="4655--4665", doi="10.1172/JCI82267", issn="0021-9738" }