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DWIVEDI, G. TIWARI, N. SINGH, A. KUMAR, A. ROY, S. NEGI, A. PAL, A. CHANDA, D. SHARMA, A. DAROKAR, M.
Originální název
Gallic acid based indanone derivative interacts synergistically with tetracycline by inhibiting efflux pump in multidrug resistant E. coli
Typ
článek v časopise ve Web of Science, Jimp
Jazyk
angličtina
Originální abstrakt
The purpose of the present study was to study the synergy potential of gallic acid-based derivatives in combination with conventional antibiotics using multidrug resistant cultures of Escherichia coli. Gallic acid-based derivatives significantly reduced the MIC of tetracycline against multidrug resistant clinical isolate of E. coli. The best representative, 3-(3,4,5-trimethoxyphenyl)-4,5,6-trimethoxyindanone-1, an indanone derivative of gallic acid, was observed to inhibit ethidium bromide efflux and ATPase which was also supported by in silico docking. This derivative extended the post-antibiotic effect and decreased the mutation prevention concentration of tetracycline. This derivative in combination with TET was able to reduce the concentration of TNFα up to 18-fold in Swiss albino mice. This derivative was nontoxic and well tolerated up to 300 mg/kg dose in subacute oral toxicity study in mice. This is the first report of gallic acid-based indanone derivative as drug resistance reversal agent acting through ATP-dependent efflux pump inhibition.
Klíčová slova
Gallic acid, Indanone derivative, Efflux pump inhibition, Synergy, ATPase, Subacute oral toxicity
Autoři
DWIVEDI, G.; TIWARI, N.; SINGH, A.; KUMAR, A.; ROY, S.; NEGI, A.; PAL, A.; CHANDA, D.; SHARMA, A.; DAROKAR, M.
Vydáno
1. 3. 2016
Nakladatel
Springer-Verlag Berlin Heidelberg
Místo
Heidelberg
ISSN
0175-7598
Periodikum
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
Ročník
100
Číslo
5
Stát
Spolková republika Německo
Strany od
2311
Strany do
2325
Strany počet
15
URL
http://link.springer.com/article/10.1007/s00253-015-7152-6
BibTex
@article{BUT121531, author="Guarav {Dwivedi} and Nimisha {Tiwari} and Aastha {Singh} and Akhil {Kumar} and Sudeep {Roy} and Arvind Singh {Negi} and Anirban {Pal} and Debabrata {Chanda} and Ashok {Sharma} and Mahendra {Darokar}", title="Gallic acid based indanone derivative interacts synergistically with tetracycline by inhibiting efflux pump in multidrug resistant E. coli", journal="APPLIED MICROBIOLOGY AND BIOTECHNOLOGY", year="2016", volume="100", number="5", pages="2311--2325", doi="10.1007/s00253-015-7152-6", issn="0175-7598", url="http://link.springer.com/article/10.1007/s00253-015-7152-6" }