Detail publikace

Tolerance of isolated rabbit hearts to short ischemic periods is affected by increased LV mass fraction

HLAVÁČOVÁ, M. OLEJNÍČKOVÁ, V. RONZHINA, M. STRAČINA, T. JANOUŠEK, O. NOVÁKOVÁ, M. BABULA, P. KOLÁŘOVÁ, J. PROVAZNÍK, I. PAULOVÁ, H.

Originální název

Tolerance of isolated rabbit hearts to short ischemic periods is affected by increased LV mass fraction

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Hypertrophied hearts are known for increased risk of arrhythmias and are linked with reduced ischemic tolerance. However, still little is known about state characterized only by increased left ventricle (LV) mass fraction. Seventeen isolated rabbit hearts with various LV mass were divided into two groups according to LV weight/heart weight ratio (LVW/HW ratio), namely group H and L (with higher and lower LVW/HW ratio, respectively) and underwent three short cycles of global ischemia and reperfusion. The differences in electrogram (heart rate, QRSmax, mean number, onset and dominant form of ventricular premature beats) and in biochemical markers of myocardial injury (creatine kinase, lactate dehydrogenase - LDH) and lipid peroxidation (4-hydroxy-2-nonenal – 4-HNE) were studied. As compared to group L, hearts in group H exhibited lower tolerance to ischemia expressed as higher incidence and severity of arrhythmias in the first ischemic period as well as increase of LDH and 4-HNE after the first perfusion. In the third cycle of ischemia-reperfusion, the preconditioning effect was observed in both electrophysiological parameters and LDH release in group H. Our results showed consistent trends when comparing changes in electrograms and biochemical markers. Moreover, 4-HNE seems to be good potential parameter of moderate membrane alteration following ischemia-reperfusion injury.

Klíčová slova

Rabbit isolated heart, LV mass, global ischemia, electrogram, 4-hydroxy-2-nonenal

Autoři

HLAVÁČOVÁ, M.; OLEJNÍČKOVÁ, V.; RONZHINA, M.; STRAČINA, T.; JANOUŠEK, O.; NOVÁKOVÁ, M.; BABULA, P.; KOLÁŘOVÁ, J.; PROVAZNÍK, I.; PAULOVÁ, H.

Vydáno

15. 2. 2017

Nakladatel

Institute of Physiology, Czech Academy of Sciences

Místo

Prague

ISSN

1802-9973

Periodikum

Physiological Research

Ročník

66

Číslo

4

Stát

Česká republika

Strany od

581

Strany do

589

Strany počet

9

BibTex

@article{BUT133120,
  author="Miroslava {Hlaváčová} and Veronika {Olejníčková} and Marina {Filipenská} and Tibor {Stračina} and Oto {Janoušek} and Marie {Nováková} and Petr {Babula} and Jana {Kolářová} and Valentine {Provazník} and Hana {Paulová}",
  title="Tolerance of isolated rabbit hearts to short ischemic periods is affected by increased LV mass fraction",
  journal="Physiological Research",
  year="2017",
  volume="66",
  number="4",
  pages="581--589",
  issn="1802-9973"
}