Detail publikace

Accurate simulation of transcranial ultrasound propagation for ultrasonic neuromodulation and stimulation

ROBERTSON, J. COX, B. JAROŠ, J. TREEBY, B.

Originální název

Accurate simulation of transcranial ultrasound propagation for ultrasonic neuromodulation and stimulation

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Non-invasive, focal neurostimulation with ultrasound is a potentially powerful neuroscientific tool that requires effective transcranial focusing of ultrasound to develop. Time-reversal (TR) focusing using numerical simulations of transcranial ultrasound propagation can correct for the effect of the skull, but relies on accurate simulations. Here, focusing requirements for ultrasonic neurostimulation are established through a review of previously employed ultrasonic parameters, and consideration of deep brain targets. The specific limitations of finite-difference time domain (FDTD) and k-space corrected pseudospectral time domain (PSTD) schemes are tested numerically to establish the spatial points per wavelength and temporal points per period needed to achieve the desired accuracy while minimizing the computational burden. These criteria are confirmed through convergence testing of a fully simulated TR protocol using a virtual skull. The k-space PSTD scheme performed as well as, or better than, the widely used FDTD scheme across all individual error tests and in the convergence of large scale models, recommending it for use in simulated TR. Staircasing was shown to be the most serious source of error. Convergence testing indicated that higher sampling is required to achieve fine control of the pressure amplitude at the target than is needed for accurate spatial targeting.

Klíčová slova

Transcranial neurostimulation, focused ultrasound, numerical simulation

Autoři

ROBERTSON, J.; COX, B.; JAROŠ, J.; TREEBY, B.

Vydáno

13. 3. 2017

ISSN

1520-8524

Periodikum

Journal of the Acoustical Society of America

Ročník

141

Číslo

3

Stát

Spojené státy americké

Strany od

1726

Strany do

1738

Strany počet

13

URL

http://asa.scitation.org/doi/10.1121/1.4976339

Plný text v Digitální knihovně

http://hdl.handle.net/11012/68367

BibTex

@article{BUT134713,
  author="James {Robertson} and Ben {Cox} and Jiří {Jaroš} and Bradley {Treeby}",
  title="Accurate simulation of transcranial ultrasound propagation for ultrasonic neuromodulation and stimulation",
  journal="Journal of the Acoustical Society of America",
  year="2017",
  volume="141",
  number="3",
  pages="1726--1738",
  doi="10.1121/1.4976339",
  issn="1520-8524",
  url="http://asa.scitation.org/doi/10.1121/1.4976339"
}