Detail publikace

Parkinson Disease Detection from Speech Articulation Neuromechanics

GOMEZ-VILDA, P. MEKYSKA, J. MANUEL FERRANDEZ, J. PALACIOS-ALONSO, D. GÓMEZ-RODELLAR, A. RODELLAR BIARGE, M. GALÁŽ, Z. SMÉKAL, Z. ELIÁŠOVÁ, I. KOŠŤÁLOVÁ, M. REKTOROVÁ, I.

Originální název

Parkinson Disease Detection from Speech Articulation Neuromechanics

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Aim: The research described is intended to give a description of articulation dynamics as a correlate of the kinematic behavior of the jaw-tongue biomechanical system, encoded as a probability distribution of an absolute joint velocity. This distribution may be used in detecting and grading speech from patients affected by neurodegenerative illnesses, as Parkinson Disease. Hypothesis: The work hypothesis is that the probability density function of the absolute joint velocity includes information on the stability of phonation when applied to sustained vowels, as well as on fluency if applied to connected speech. Methods: A dataset of sustained vowels recorded from Parkinson Disease patients is contrasted with similar recordings from normative subjects. The probability distribution of the absolute kinematic velocity of the jaw-tongue system is extracted from each utterance. A Random Least Squares Feed-Forward Network (RLSFN) has been used as a binary classifier working on the pathological and normative datasets in a leave-one-out strategy. Monte Carlo simulations have been conducted to estimate the influence of the stochastic nature of the classifier. Two datasets for each gender were tested (males and females) including 26 normative and 53 pathological subjects in the male set, and 25 normative and 38 pathological in the female set. Results: Male and female data subsets were tested in single runs, yielding equal error rates under 0.6% (Accuracy over 99.4%). Due to the stochastic nature of each experiment, Monte Carlo runs were conducted to test the reliability of the methodology. The average detection results after 200 Montecarlo runs of a 200 hyperplane hidden layer RLSFN are given in terms of Sensitivity (males: 0.9946, females: 0.9942), Specificity (males: 0.9944, females: 0.9941) and Accuracy (males: 0.9945, females: 0.9942). The area under the ROC curve is 0.9947 (males) and 0.9945 (females). The equal error rate is 0.0054 (males) and 0.0057 (females). Conclusions: The proposed methodology avails that the use of highly normalized descriptors as the probability distribution of kinematic variables of vowel articulation stability, which has some interesting properties in terms of information theory, boosts the potential of simple yet powerful classifiers in producing quite acceptable detection results in Parkinson Disease.

Klíčová slova

neurologic disease, Parkinson disease, speech neuromotor activity, aging voice, hypokinetic dysarthria, random least squares feed-forward networks

Autoři

GOMEZ-VILDA, P.; MEKYSKA, J.; MANUEL FERRANDEZ, J.; PALACIOS-ALONSO, D.; GÓMEZ-RODELLAR, A.; RODELLAR BIARGE, M.; GALÁŽ, Z.; SMÉKAL, Z.; ELIÁŠOVÁ, I.; KOŠŤÁLOVÁ, M.; REKTOROVÁ, I.

Vydáno

25. 8. 2017

Nakladatel

Frontiers

ISSN

1662-5196

Periodikum

Frontiers in Neuroinformatics

Ročník

11

Číslo

56

Stát

Švýcarská konfederace

Strany od

1

Strany do

17

Strany počet

17

URL

Plný text v Digitální knihovně

BibTex

@article{BUT138682,
  author="Pedro {Gomez-Vilda} and Jiří {Mekyska} and Jose {Manuel Ferrandez} and Daniel {Palacios-Alonso} and Andrés {Gómez-Rodellar} and María Victoria {Rodellar Biarge} and Zoltán {Galáž} and Zdeněk {Smékal} and Ilona {Eliášová} and Milena {Košťálová} and Irena {Rektorová}",
  title="Parkinson Disease Detection from Speech Articulation Neuromechanics",
  journal="Frontiers in Neuroinformatics",
  year="2017",
  volume="11",
  number="56",
  pages="1--17",
  doi="10.3389/fninf.2017.00056",
  issn="1662-5196",
  url="http://journal.frontiersin.org/article/10.3389/fninf.2017.00056/full"
}