Detail publikace

Effect of Transmural Differences in Excitation-Contraction Delay and Contraction Velocity on Left Ventricle Isovolumic Contraction: A Simulation Study

VAVERKA, J. BURŠA, J. ŠUMBERA, J. PÁSEK, M.

Originální název

Effect of Transmural Differences in Excitation-Contraction Delay and Contraction Velocity on Left Ventricle Isovolumic Contraction: A Simulation Study

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Recent studies have shown that left ventricle (LV) exhibits considerable transmural differences in active mechanical properties induced by transmural differences in electrical activity, excitation-contraction coupling, and contractile properties of individual myocytes. It was shown that the time between electrical and mechanical activation of myocytes (electromechanical delay: EMD) decreases from subendocardium to subepicardium and, on the contrary, the myocyte shortening velocity (MSV) increases in the same direction. To investigate the physiological importance of this inhomogeneity, we developed a new finite element model of LV incorporating the observed transmural gradients in EMD and MSV. Comparative simulations with the model showed that when EMD or MSV or both were set constant across the LV wall, the LV contractility during isovolumic contraction (IVC) decreased significantly ((/)max was reduced by 2 to 38% and IVC was prolonged by 18 to 73%). This was accompanied by an increase of transmural differences in wall stress.These results suggest that the transmural differences in EMD and MSV play an important role in physiological contractility of LV by synchronising the contraction of individual layers of ventricular wall during the systole. Reduction or enhancement of these differences may therefore impair the function of LV and contribute to heart failure.

Klíčová slova

left ventricle; isovolumic contraction; transmural heterogeneity; finite element model

Autoři

VAVERKA, J.; BURŠA, J.; ŠUMBERA, J.; PÁSEK, M.

Vydáno

10. 5. 2018

Nakladatel

Hindawi

Místo

London, United Kingdom

ISSN

2314-6141

Periodikum

BioMed Research International

Ročník

2018

Číslo

2018

Stát

Spojené státy americké

Strany od

1

Strany do

10

Strany počet

10

URL

http://dx.doi.org/10.1155/2018/4798512

Plný text v Digitální knihovně

http://hdl.handle.net/11012/72424

BibTex

@article{BUT147339,
  author="Jiří {Vaverka} and Jiří {Burša} and Josef {Šumbera} and Michal {Pásek}",
  title="Effect of Transmural Differences in Excitation-Contraction Delay and Contraction Velocity on Left Ventricle Isovolumic Contraction: A Simulation Study",
  journal="BioMed Research International",
  year="2018",
  volume="2018",
  number="2018",
  pages="1--10",
  doi="10.1155/2018/4798512",
  issn="2314-6141",
  url="http://dx.doi.org/10.1155/2018/4798512"
}