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OLEJNÍČKOVÁ, V. JANOUŠEK, O. RONZHINA, M. HEJČ, J. KVASILOVA, A. ZABRODSKA, E. SEDMERA, D.
Originální název
Optical mapping can reveal two dimensional morphology of atrioventricular insulation in the foetal avian heart
Typ
článek ve sborníku ve WoS nebo Scopus
Jazyk
angličtina
Originální abstrakt
Syndromes of ventricular pre-excitation or atrio-ventricular (AV) re-entry are believed to results from inappropriate formation of AV junction (AVJ) during prenatal development. However, technical limitations have challenge to study foetal heart electrophysiology and are hampering the understanding formation of accessory pathways (APs) bypassing AVJ. Here, we present a novel approach of rethrograde perfusion for optical mapping of chicken foetal heart. Together with embryonic heart mapping, we were able to investigate AVJ electrical remodelling during whole prenatal periods. AV electrical insulation was observed concomitant to functional deployment of the conduction system at the time of ventricular septation. However, persistence of AV electrical continuity was still detected in post-septated foetal hearts. APs registered in 40% of prenatal day 13 (localised in the central anterior or left posterior side) were progressively resolved and none APs were detected in prenatal day 18. The optical mapping approach thus proved its ability to track AVJ electrical remodelling and spatiotemporally localise electrically active APs in the critical growing eriods.
Klíčová slova
Optical mapping, action potential, di-4-ANEPPS, AV junction remodelling, foetal avian heart
Autoři
OLEJNÍČKOVÁ, V.; JANOUŠEK, O.; RONZHINA, M.; HEJČ, J.; KVASILOVA, A.; ZABRODSKA, E.; SEDMERA, D.
Vydáno
26. 9. 2018
Místo
Maastricht
ISSN
2325-887X
Periodikum
Computing in Cardiology
Ročník
45
Číslo
1
Stát
Spojené státy americké
Strany od
Strany do
4
Strany počet
URL
https://ieeexplore.ieee.org/document/8744067
BibTex
@inproceedings{BUT151034, author="OLEJNÍČKOVÁ, V. and JANOUŠEK, O. and RONZHINA, M. and HEJČ, J. and KVASILOVA, A. and ZABRODSKA, E. and SEDMERA, D.", title="Optical mapping can reveal two dimensional morphology of atrioventricular insulation in the foetal avian heart", booktitle="Computing in Cardiology 2018", year="2018", journal="Computing in Cardiology", volume="45", number="1", pages="1--4", address="Maastricht", doi="10.22489/CinC.2018.055", issn="2325-887X", url="https://ieeexplore.ieee.org/document/8744067" }