Detail publikace

In-situ Observation of Lyophilization Process in Environmental Scanning Electron Microscope

VETRÁKOVÁ, Ľ. NEDĚLA, V. RUNŠTUK, J. TIHLAŘÍKOVÁ, E. IMRICHOVÁ, K.

Originální název

In-situ Observation of Lyophilization Process in Environmental Scanning Electron Microscope

Typ

abstrakt

Jazyk

angličtina

Originální abstrakt

Lyophilization (freeze-drying) is nowadays the most common formulation strategy to prepare pharmaceuticals as in the solid state chemical or physical degradation reactions are inhibited or sufficiently decelerated. Here we present dynamical in-situ monitoring of the drying step in lyophilisation of 5% (w/w) BSA solution inside environmental scanning electron microscope (ESEM) under pharmaceutically relevant conditions. We observed the changes in microstructure of the protein during drying at the temperature of −20 °C and the pressure of 700 Pa.

Klíčová slova

lyophilization, BSA, ESEM, freezing

Autoři

VETRÁKOVÁ, Ľ.; NEDĚLA, V.; RUNŠTUK, J.; TIHLAŘÍKOVÁ, E.; IMRICHOVÁ, K.

Vydáno

10. 10. 2018

Místo

Saarbrücken, Germany

Strany od

114

Strany do

115

Strany počet

2

BibTex

@misc{BUT152657,
  author="Ľubica {Vetráková} and Vilém {Neděla} and Jiří {Runštuk} and Eva {Tihlaříková} and Kamila {Závacká}",
  title="In-situ Observation of Lyophilization Process in Environmental Scanning Electron Microscope",
  year="2018",
  pages="114--115",
  address="Saarbrücken, Germany",
  note="abstract"
}