Detail publikace

Bisphosphonates-much more than only drugs for bone diseases

KUŹNIK, A. PAŹDZIERNIOK-HOLEWA, A. JEWULA, P. KUŹNIK, N.

Originální název

Bisphosphonates-much more than only drugs for bone diseases

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

alpha,alpha-Bisphosphonates (BPs) are well established in the treatment of bone diseases such as osteoporosis and Paget's disease. Their successful application originates from their high affinity to hydroxyapatite. While the initially appreciated features of BPs are already beneficial to many patients, recent developments have further expanded their pleiotropic applications. This review describes the background of the interactions of BPs with bone cells that form the basis of the classical treatment. A better understanding of the mechanism behind their interactions allows for the parallel application of BPs against bone cancer and metastases followed by palliative pain relief. Targeted therapy with bone-seeking BPs coupled with a diagnostic agent in one particle resulted in theranostics which is also described here. For example, in such a system, BP moieties are bound to contrast agents used in magnetic resonance imaging or radionuclides used in positron emission tomography. In addition, another example of the pleiotropic function of BPs which involves targeting the imaging agents to bone tissues accompanied by pain reduction is presented in this work.

Klíčová slova

Bisphosphonate; Bone disease; Osteoporosis; Paget's disease; Bone imaging; Bone metastasis

Autoři

KUŹNIK, A.; PAŹDZIERNIOK-HOLEWA, A.; JEWULA, P.; KUŹNIK, N.

Vydáno

5. 1. 2020

Nakladatel

ELSEVIER

Místo

AMSTERDAM

ISSN

0014-2999

Periodikum

European Journal of Pharmacology

Ročník

866

Číslo

1

Stát

Nizozemsko

Strany od

1

Strany do

16

Strany počet

16

URL

https://www.sciencedirect.com/science/article/pii/S0014299919307253?via%3Dihub

BibTex

@article{BUT161177,
  author="Anna {Kuźnik} and Agnieszka {Październiok-Holewa} and Pawel {Jewula} and Nikodem {Kuźnik}",
  title="Bisphosphonates-much more than only drugs for bone diseases",
  journal="European Journal of Pharmacology",
  year="2020",
  volume="866",
  number="1",
  pages="1--16",
  doi="10.1016/j.ejphar.2019.172773",
  issn="0014-2999",
  url="https://www.sciencedirect.com/science/article/pii/S0014299919307253?via%3Dihub"
}