Detail publikace

Imaging video plethysmography shows reduced signal amplitude in glaucoma patients in the area of the microvascular tissue of the optic nerve head

TORNOW, R. KOLÁŘ, R. ODSTRČILÍK, J. LABOUNKOVÁ, I. HORN, F.

Originální název

Imaging video plethysmography shows reduced signal amplitude in glaucoma patients in the area of the microvascular tissue of the optic nerve head

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Purpose To measure parameters of the cardiac cycle-induced pulsatile light absorption signal (plethysmography signal) of the optic nerve head (ONH) and to compare parameters between normal subjects and patients with different stages of glaucoma. Patients and methods A recently developed video ophthalmoscope was used to acquire short video sequences (10 s) of the ONH. After image registration and trend correction, the pulsatile changing light absorption at the ONH tissue (excluding large vessels) was calculated. The changing light absorption depends on the pulsatile changing blood volume. Various parameters, including peak amplitude, steepness, time-to-peak, full width at half maximum (FWHM), and pulse duration, were calculated for averaged individual pulses (heartbeats) of the plethysmography signal. This method was applied to 19 healthy control subjects and 91 subjects with ocular hypertension, as well as different stages of primary open-angle glaucoma (17 subjects with ocular hypertension, 24 with preperimetric glaucoma, and 50 with perimetric glaucoma). Results Compared to the normal subjects, significant reductions (p < 0.001) in peak amplitude and steepness were observed in the group of perimetric glaucoma patients, but no significant difference was found for time-to-peak, FWHM, and pulse duration. Peak amplitude and steepness showed high correlations with RNFL thickness (p < 0.001). Conclusions The presented low-cost video-ophthalmoscope permits measurement of the plethysmographic signal of the ONH tissue and calculation of different blood flow-related parameters. The reduced values of the amplitude and steepness parameters in perimetric glaucoma patients suggest decreased ONH perfusion and blood volume. This outcome is in agreement with results from other studies using OCT angiography and laser speckle flowgraphy, which confirm reduced capillary density in these patients.

Klíčová slova

Retinal plethysmography; Glaucoma; Perfusion; Blood volume; Blood flow

Autoři

TORNOW, R.; KOLÁŘ, R.; ODSTRČILÍK, J.; LABOUNKOVÁ, I.; HORN, F.

Vydáno

23. 9. 2020

Nakladatel

Springer

ISSN

0721-832X

Periodikum

GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Číslo

1

Stát

Spojené státy americké

Strany od

1

Strany do

12

Strany počet

12

URL

https://link.springer.com/article/10.1007%2Fs00417-020-04934-y

Plný text v Digitální knihovně

http://hdl.handle.net/11012/195242

BibTex

@article{BUT165363,
  author="Ralf-Peter {Tornow} and Radim {Kolář} and Jan {Odstrčilík} and Ivana {Labounková} and Folkert {Horn}",
  title="Imaging video plethysmography shows reduced signal amplitude in glaucoma patients in the area of the microvascular tissue of the optic nerve head",
  journal="GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY",
  year="2020",
  number="1",
  pages="1--12",
  doi="10.1007/s00417-020-04934-y",
  issn="0721-832X",
  url="https://link.springer.com/article/10.1007%2Fs00417-020-04934-y"
}