Detail publikace

Physicochemical Characterization, Molecular Docking, and In Vitro Dissolution of Glimepiride−Captisol Inclusion Complexes

PAL, A. ROY, S. KUMAR, A. MAHMOOD, S. KHODAPANAH, N. THOMAS, S. AGATEMOR, C. GHOSAL, K.

Originální název

Physicochemical Characterization, Molecular Docking, and In Vitro Dissolution of Glimepiride−Captisol Inclusion Complexes

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

This present study investigated the effect of Captisol, a chemically modified cyclodextrin, on the in vitro dissolution of glimepiride. We prepared glimepiride−Captisol complexes of different mass ratios (1:1, 1:2, and 1:3 w/w) by a physical mixing or freeze-drying technique, and found that complexation with Captisol enhanced the water solubility of glimepiride. Molecular docking and dynamic simulation predicted complex formation; at the same time, Fourier transform infrared spectroscopy, differential scanning calorimetry, powder X-ray diffractometry, and scanning electron microscope indicated molecular interactions that support complexation. We also found that an inclusion complex was better than a physical mixture in enhancing the complexation of glimepiride with Captisol and enhancing water solubility. Phase solubility study of the glimepiride−Captisol complex showed an AL-type profile, implying the formation of a 1:1 inclusion complex. The study also revealed that pH influenced the stability of the complex because the stability constant of the glimepiride−Captisol complex was higher in distilled water of pH ∼6.0 than in phosphate buffer of pH 7.2.

Klíčová slova

Glimepiride;Captisol;molecular docking;molecular simulation

Autoři

PAL, A.; ROY, S.; KUMAR, A.; MAHMOOD, S.; KHODAPANAH, N.; THOMAS, S.; AGATEMOR, C.; GHOSAL, K.

Vydáno

1. 8. 2020

Nakladatel

American Chemical Society

Místo

USA

ISSN

2470-1343

Periodikum

ACS OMEGA

Ročník

5

Číslo

32

Stát

Spojené státy americké

Strany od

19968

Strany do

19977

Strany počet

10

URL

https://pubs.acs.org/doi/10.1021/acsomega.0c01228

Plný text v Digitální knihovně

http://hdl.handle.net/11012/196516

BibTex

@article{BUT165567,
  author="Arpita {Pal} and Sudeep {Roy} and Akhil {Kumar} and Syed {Mahmood} and Nasrin {Khodapanah} and Sabu {Thomas} and Christian {Agatemor} and Kajal {Ghosal}",
  title="Physicochemical Characterization, Molecular Docking, and In Vitro Dissolution of Glimepiride−Captisol Inclusion Complexes",
  journal="ACS OMEGA",
  year="2020",
  volume="5",
  number="32",
  pages="19968--19977",
  doi="10.1021/acsomega.0c01228",
  issn="2470-1343",
  url="https://pubs.acs.org/doi/10.1021/acsomega.0c01228"
}