Detail publikace

A new insight into more effective viscosupplementation based on the synergy of hyaluronic acid and phospholipids for cartilage friction reduction

HILŠER, P. SUCHÁNKOVÁ, A. MENDOVÁ, K. FILIPIČ, K.E. DANIEL, M. VRBKA, M.

Originální název

A new insight into more effective viscosupplementation based on the synergy of hyaluronic acid and phospholipids for cartilage friction reduction

Typ

článek v časopise ve Scopus, Jsc

Jazyk

angličtina

Originální abstrakt

Osteoarthritis is a joint disease characterized by progressive damage to the cartilage. For a long time, viscosupplements have been based on hyaluronic acid (HA), which is known to relieve the pain of osteoarthritic patients. Recently, however, it has been hypothesized that phospholipids and HA may be collectively responsible for the extremely low friction observed in joint models (mica tape), suggesting that such a combination might lead to more effective viscosupplements. Using a pin-on-plate tribometer, we have tested this hypothesis by analyzing the coefficient of friction of conventional HA viscosupplements compared to the new viscosupplement formula of phospholipids and HA. Our findings show that phospholipids and HA do indeed lead to the lowest friction in the joints at both cartilage-mica tape and cartilage-glass interfaces (joint models). Furthermore, these results also hold true when both viscosupplements are mixed with synovial fluid simulating the real conditions after viscosupplement injection into joints. Therefore, we have validated the synergic effect of phospholipids and HA on lowering the cartilage friction and we further hypothesized that this effect is due to hydration lubrication. We believe these findings might contribute to development of new viscosupplement which would significantly improve the lives of person suffering from osteoarthrosis.

Klíčová slova

Articular cartilage; Viscosupplement; Hyaluronic acid; Phospholipids; Mica; Hydration lubrication; Friction

Autoři

HILŠER, P.; SUCHÁNKOVÁ, A.; MENDOVÁ, K.; FILIPIČ, K.E.; DANIEL, M.; VRBKA, M.

Vydáno

6. 2. 2021

Nakladatel

Elsevier Ltd

Místo

Radarweg 29, 1043 NX Amsterdam, The Netherlands

ISSN

2352-5738

Periodikum

Biotribology

Ročník

25

Číslo

1

Stát

Spojené království Velké Británie a Severního Irska

Strany od

100166

Strany do

100166

Strany počet

11

URL

https://www.sciencedirect.com/science/article/pii/S235257382100007X

BibTex

@article{BUT169575,
  author="HILŠER, P. and SUCHÁNKOVÁ, A. and MENDOVÁ, K. and FILIPIČ, K.E. and DANIEL, M. and VRBKA, M.",
  title="A new insight into more effective viscosupplementation based on the synergy of hyaluronic acid and phospholipids for cartilage friction reduction",
  journal="Biotribology",
  year="2021",
  volume="25",
  number="1",
  pages="100166--100166",
  doi="10.1016/j.biotri.2021.100166",
  issn="2352-5738",
  url="https://www.sciencedirect.com/science/article/pii/S235257382100007X"
}