Detail publikace

A composite device for viscosupplementation treatment resistant to degradation by reactive oxygen species and hyaluronidase

TOROPITSYN, E. PRAVDA, M. REBENDA, D. ŠČIGALKOVÁ, I. VRBKA, M. VELEBNÝ, V.

Originální název

A composite device for viscosupplementation treatment resistant to degradation by reactive oxygen species and hyaluronidase

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Osteoarthritis (OA) is one of the most common musculoskeletal disorders in the world. OA is often associated with the loss of viscoelastic and tribological properties of synovial fluid (SF) due to degradation of hyaluronic acid (HA) by reactive oxygen species (ROS) and hyaluronidases. Viscosupplementation is one of the ways how to effectively restore SF functions. However, current viscosupplementation products provide only temporal therapeutic effect because of short biological half-life. In this article we describe a novel device for viscosupplementation (NV) based on the cross-linked tyramine derivative of HA, chondroitin sulfate (CS), and high molecular weight HA by online determination of viscoelastic properties loss during degradation by ROS and hyaluronidase. Rheological and tribological properties of developed viscosupplement were compared with HA solutions with different molecular weights in the range 500–2000 kDa, which are currently commonly used as medical devices for viscosupplementation treatment. Moreover, based on clinical practice and scientific literature all samples were also diluted by model OA SF in the ratio 1:1 (vol/vol) to better predict final properties after injection to the joint. The observed results confirmed that NV exhibits appropriate rheological properties (viscosity, elastic, and viscous moduli) comparable with healthy SF and maintain them during degradation for a significantly longer time than HA solutions with molecular weight in the range 500–2000 kDa and cross-linked material without CS.

Klíčová slova

hyaluronidase, ROS, tyramine derivative of hyaluronic acid, viscoelastic properties,viscosupplementation

Autoři

TOROPITSYN, E.; PRAVDA, M.; REBENDA, D.; ŠČIGALKOVÁ, I.; VRBKA, M.; VELEBNÝ, V.

Vydáno

21. 6. 2022

Nakladatel

John Wiley & Sons Inc.

Místo

Hoboken, New Jersey, USA

ISSN

1552-4981

Periodikum

Journal of biomedical materials research. Part B, Applied biomaterials (Electronic)

Ročník

110

Číslo

2

Stát

Spojené státy americké

Strany od

2595

Strany do

2611

Strany počet

17

URL

https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.b.35114

BibTex

@article{BUT178319,
  author="Evgeniy {Toropitsyn} and Martin {Pravda} and David {Rebenda} and Ivana {Ščigalková} and Martin {Vrbka} and Vladimír {Velebný}",
  title="A composite device for viscosupplementation treatment resistant to degradation by reactive oxygen species and hyaluronidase",
  journal="Journal of biomedical materials research. Part B, Applied biomaterials (Electronic)",
  year="2022",
  volume="110",
  number="2",
  pages="2595--2611",
  doi="10.1002/jbm.b.35114",
  issn="1552-4981",
  url="https://onlinelibrary.wiley.com/doi/abs/10.1002/jbm.b.35114"
}