Drug transport in urban soil through the seasons in a combination of X-ray computed tomography and chemical analyses: Preliminary results

abstrakt

angličtina

We combined X-ray computed tomography with common chemical analyses to observe seasonal changes (Spring, Summer, Autumn) in natural urban grassland soil and the impact on drug transport. Soil is an essential material for life on earth due to its numerous functions. Its modification has important long term economic, environmental, and ecological impacts [1]. Drug diffusion and permeability of soil impact its functions through its contamination rate and spread, which changes its usability. Soil is heavily structured by its organic content (fauna, flora) [2], which creates voids and networks. Also, soil disaggregation and solubility impact the movement of drug molecules [3,4]. Most studies focus on croplands or natural soil [5], on transport studies realized under artificial laboratory conditions or on computer solute transport modelling [6,7]. We think that a study on natural soil is important to assess the reality in a more comprehensive way. For this work, the top layer (10 cm) from an urban soil was sampled, which is directly impacted by the climate and its direct environment. It is also the entrance point of the drugs (Fig. 1). The soil just sampled was scanned with a microCT system directly in its sampling device and then its humidity and chemistry (thermogravimetry, FTIR, elemental analysis) were analysed as well as its diffusion coefficient with chosen drug molecules (sulfapyridine, sulfamethoxazole). The scanned soil was segmented into organic matter, pores (open/closed) and the matrix with VG Studio (Fig. 1A). The segmentation between organic matter and pores was challenging as they have low contrast. We ran molecular diffusion and permeability simulation (Fig. 1B) based on the chemical parameters and results measured on the same soil sample and then compared the CT analyses to the chemical ones.

Drug Transport; Seasonal changes; microCT; Chemistry; Urban soil; Diffusion

JAQUES, V.; ZÁVODSKÁ, P.; KLUČÁKOVÁ, M.; PEKAŘ, M.; ZIKMUND, T.; KAISER, J.

8. 9. 2022

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https://www.toscainternational.org/2022qmul/welcome

ToScA_2022.pdf
2201-DT_ToSCa2022_Abstract.pdf