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TRUDIČOVÁ, M. PAPEŽÍKOVÁ, H. SEDLÁČEK, P. PEKAŘ, M.
Originální název
Tailoring the internal microstructue of the hydrogels based on poly-HEMA targeted for drug delivery systems
Typ
abstrakt
Jazyk
angličtina
Originální abstrakt
The transport and barrier properties are important material characteristics in terms of the development of the targeted drug delivery systems. Therefore, this work focused on the study of the possibility of influencing these properties and internal architecture in a model hydrogel system formed by a semi-interpenetrating polymer network with an incorporated polyelectrolyte component. Due to its application potential and its extensive use in medicine, poly(2-hydroxyethyl methacrylate) was chosen as the model hydrogel system for this work. Sodium polystyrene sulfonate was used as the interpenetrating linear polymer. Scanning electron microscopy was used to examine the structure of the three-dimensional hydrogel network. Transport properties were monitored by diffusion tests. Furthermore, diffusion through the hydrogel (barrier properties) was monitored using diffusion cells (Franz cells, horizontal cells). The usability of the semi-interpenetrating polymer network concept for the preparation of materials with tunable relevant properties was confirmed on the proposed materials.
Klíčová slova
hydrogel, poly(2-hydroxyethyl methacrylate), transport properties, drug delivery systems
Autoři
TRUDIČOVÁ, M.; PAPEŽÍKOVÁ, H.; SEDLÁČEK, P.; PEKAŘ, M.
Vydáno
20. 10. 2021
Nakladatel
Tanger Ltd.
Místo
Ostrava, CZ
ISBN
978-80-88365-00-6
Kniha
Nanocon 2021 Abstracts 13th International Conference on Nanomaterials - Research & Application
Edice
1
Strany od
105
Strany do
Strany počet
BibTex
@misc{BUT179524, author="Monika {Trudičová} and Hana {Papežíková} and Petr {Sedláček} and Miloslav {Pekař}", title="Tailoring the internal microstructue of the hydrogels based on poly-HEMA targeted for drug delivery systems", booktitle="Nanocon 2021 Abstracts 13th International Conference on Nanomaterials - Research & Application", year="2021", series="1", pages="105--105", publisher="Tanger Ltd.", address="Ostrava, CZ", isbn="978-80-88365-00-6", note="abstract" }