Detail publikace

Self-Propelled Magnetic Dendrite-Shaped Microrobots for Photodynamic Prostate Cancer Therapy

PENG, X. URSO, M. BALVAN, J. MASAŘÍK, M. PUMERA, M.

Originální název

Self-Propelled Magnetic Dendrite-Shaped Microrobots for Photodynamic Prostate Cancer Therapy

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Photocatalytic micromotors that exhibit wireless and controllable motion by light have been extensively explored for cancer treatment by photodynamic therapy (PDT). However, overexpressed glutathione (GSH) in the tumor microenvironment can down-regulate the reactive oxygen species (ROS) level for cancer therapy. Herein, we present dendrite-shaped light-powered hematite microrobots as an effective GSH depletion agent for PDT of prostate cancer cells. These hematite microrobots can display negative phototactic motion under light irradiation and flexible actuation in a defined path controlled by an external magnetic field. Non-contact transportation of micro-sized cells can be achieved by manipulating the microrobot's motion. In addition, the biocompatible microrobots induce GSH depletion and greatly enhance PDT performance. The proposed dendrite-shaped hematite microrobots contribute to developing dual light/magnetic field-powered micromachines for the biomedical field.

Klíčová slova

Cargo Transportation; Micromachines; Micromotors; Photocatalysis; Tumor Cells

Autoři

PENG, X.; URSO, M.; BALVAN, J.; MASAŘÍK, M.; PUMERA, M.

Vydáno

25. 11. 2022

Nakladatel

WILEY-V C H VERLAG GMBH

Místo

WEINHEIM

ISSN

1521-3773

Periodikum

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ročník

61

Číslo

48

Stát

Spolková republika Německo

Strany počet

8

URL

https://onlinelibrary.wiley.com/doi/10.1002/anie.202213505

BibTex

@article{BUT181618,
  author="Xia {Peng} and Mario {Urso} and Jan {Balvan} and Michal {Masařík} and Martin {Pumera}",
  title="Self-Propelled Magnetic Dendrite-Shaped Microrobots for Photodynamic Prostate Cancer Therapy",
  journal="ANGEWANDTE CHEMIE-INTERNATIONAL EDITION",
  year="2022",
  volume="61",
  number="48",
  pages="8",
  doi="10.1002/anie.202213505",
  issn="1521-3773",
  url="https://onlinelibrary.wiley.com/doi/10.1002/anie.202213505"
}