Detail publikace

3D printed Calcium Phosphate Cements enriched with liposome-encapsulated antibacterial enzymes for bone infection treatment

KADLECOVÁ, Z. LYSÁKOVÁ, K. VOJTOVÁ, L.

Originální název

3D printed Calcium Phosphate Cements enriched with liposome-encapsulated antibacterial enzymes for bone infection treatment

Typ

abstrakt

Jazyk

angličtina

Originální abstrakt

Three-dimensional (3D) printing has been in focus in recent years. Via this method, it is possible to prepare bioactive, patient-specific porous scaffolds1. The process of p of the 3D printed scaffold is often accompanied by several microorganisms, which can lead to a bone infection known as osteomyelitis2. The combination of the thermosensitive copolymer, the calcium phosphate powder and suitable enzymes gives an ideal combination for 3D printing of bone implants with well-defined pore size, mechanical properties, degradation rate, as well as antibacterial activity. Therefore, as the scaffold resorbs, the antibacterial enzymes are released and the osteomyelitis can be suppressed. Unfortunately, as our previous study discovered, the incorporated enzymes do not release in sufficient amounts, due to the microstructure of the 3D-printed scaffold. In this project, the antibacterial enzyme lysozyme was encapsulated into liposomes, providing additional chemical and physical protection to the enzyme during the scaffold curing.

Klíčová slova

liposomes, antibacterial, calcium phosphate cement, release, lysostaphine

Autoři

KADLECOVÁ, Z.; LYSÁKOVÁ, K.; VOJTOVÁ, L.

Vydáno

17. 4. 2023

Nakladatel

Czech Chemical Society

ISSN

2336-7210

Periodikum

Czech Chemical Society Symposium Series

Ročník

21

Číslo

2

Stát

Česká republika

Strany od

88

Strany do

88

Strany počet

56

URL

http://www.ccsss.cz/index.php/ccsss/issue/view/38/69

BibTex

@misc{BUT183517,
  author="Zuzana {Kadlecová} and Klára {Tušlová} and Lucy {Vojtová}",
  title="3D printed Calcium Phosphate Cements enriched with liposome-encapsulated antibacterial enzymes for bone infection treatment",
  year="2023",
  journal="Czech Chemical Society Symposium Series",
  volume="21",
  number="2",
  pages="88--88",
  publisher="Czech Chemical Society",
  issn="2336-7210",
  url="http://www.ccsss.cz/index.php/ccsss/issue/view/38/69",
  note="abstract"
}