Detail publikace

IN SILICO HEMODYNAMICAL SIMULATIONS SHOW SECONDARY BENEFITS OF ANTIHYPERTENSIVE DRUGS

JAGOŠ, J. KOHÚT, J. NOVOTNÝ, T. KŘIVKA, T. HÁJEK, P. FORMÁNEK, M. BURŠA, J.

Originální název

IN SILICO HEMODYNAMICAL SIMULATIONS SHOW SECONDARY BENEFITS OF ANTIHYPERTENSIVE DRUGS

Typ

článek ve sborníku mimo WoS a Scopus

Jazyk

angličtina

Originální abstrakt

Although preventable, hypertension and hypertensive renal disease remain one of the major global risk factors for cardiovascular diseases, especially in the developed world [1]. Hypertension is defined as a chronically increased blood pressure (BP) above 140/90 mmHg and is related to an increase in peripheral resistance and decrease in arterial distensibility [2], similarly to an aging [1]. Available evidence confirms the ability of all five basic groups of antihypertensives to decrease arterial stiffness and consequently the BP in the long-term application [3]. Although proper treatment of hypertension attenuates its influence, the mechanisms by which hypertension accelerates atherosclerosis are poorly understood [4]. It is known that flow waveform for older subjects differs substantially from the young one mainly due to elevated arterial stiffness and consequently early wave reflection [5]. Moreover, the decreasing arterial stiffness via proper treatment of hypertension shifts the shape of the flow waveform to a young and healthy one [6]. Since arterial stiffness can be lowered through long-term application of antihypertensives, benefits of medical therapy could be not only in lowering the BP and peripheral resistance but also in improving the hemodynamic conditions.

Klíčová slova

HEMODYNAMICAL SIMULATIONS; ANTIHYPERTENSIVE DRUGS

Autoři

JAGOŠ, J.; KOHÚT, J.; NOVOTNÝ, T.; KŘIVKA, T.; HÁJEK, P.; FORMÁNEK, M.; BURŠA, J.

Vydáno

9. 7. 2023

Místo

Maastricht

Strany počet

1

URL

https://esbiomech.org/conference/wp-content/uploads/2023/ESB2023_Book_of_Abstracts.pdf

BibTex

@inproceedings{BUT184917,
  author="Jiří {Jagoš} and Jiří {Kohút} and Tomáš {Novotný} and Tomáš {Křivka} and Petr {Hájek} and Martin {Formánek} and Jiří {Burša}",
  title="IN SILICO HEMODYNAMICAL SIMULATIONS SHOW SECONDARY BENEFITS OF ANTIHYPERTENSIVE DRUGS",
  booktitle="ESB 2023 BOOK OF ABSTRACTS",
  year="2023",
  number="28",
  pages="1",
  address="Maastricht",
  url="https://esbiomech.org/conference/wp-content/uploads/2023/ESB2023_Book_of_Abstracts.pdf"
}