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EZATI, M. SAADATI, A. CAO, H. ZUMBERG, I. ČMIEL, V. LUKAS, R.
Originální název
INFLUENCE OF PC3-DERIVED EXOSOMES ON FIBROBLAST PROLIFERATION AND MIGRATION
Typ
článek ve sborníku ve WoS nebo Scopus
Jazyk
angličtina
Originální abstrakt
Nano-sized exosomes are essential for intercellular communication, especially in cancer biology. Human produces exosomes that may modulate the tumor microenvironment and cellular behavior. This study examines how human prostate cancer cells (PC3) derived exosomes affect fibroblast proliferation and migration. Ultracentrifugation isolated exosomes from PC3 cell culture supernatants, which were characterized by confocal and transmission electron microscopy (TEM). Fibroblast cells were exposed to these PC3-derived exosomes. MTT [3–(4,5-dimethylthiazol-2yl)-2,5-diphenyl-2H-tetrazoliumbromide] was used to measure fibroblast proliferation, while another assay measured migration. PC3 exosomes appear to boost fibroblast proliferation and migration. Investigations into the molecular mechanisms behind these observations are ongoing. The study shows that PC3-derived exosomes can regulate fibroblast proliferation and migration. This study illuminates the effects of cancer cell-derived exosomes on cellular interactions and therapeutic potential.
Klíčová slova
Human prostate cancer cell (PC3), exosomes, fibroblast proliferation and migration
Autoři
EZATI, M.; SAADATI, A.; CAO, H.; ZUMBERG, I.; ČMIEL, V.; LUKAS, R.
Vydáno
13. 12. 2023
Nakladatel
TANGER Ltd.
Místo
Ostrava, Czech Republic
ISBN
978-80-88365-15-0
Kniha
CONFERENCE PROCEEDINGS - NANOCON 2023
Edice
1
ISSN
2694-930X
Periodikum
Proceedings 12th International Conference on Nanomaterials - Research & Application
Stát
Česká republika
Strany od
268
Strany do
272
Strany počet
5
URL
https://doi.org/10.37904/nanocon.2023.4802
BibTex
@inproceedings{BUT185088, author="Masoumeh {Ezati} and Arezoo {Saadati} and Hoang-Anh {Cao} and Inna {Zumberg} and Vratislav {Čmiel} and Richtera {Lukas}", title="INFLUENCE OF PC3-DERIVED EXOSOMES ON FIBROBLAST PROLIFERATION AND MIGRATION", booktitle="CONFERENCE PROCEEDINGS - NANOCON 2023", year="2023", series="1", journal="Proceedings 12th International Conference on Nanomaterials - Research & Application", pages="5", publisher="TANGER Ltd.", address="Ostrava, Czech Republic", doi="10.37904/nanocon.2023.4802", isbn="978-80-88365-15-0", issn="2694-930X", url="https://doi.org/10.37904/nanocon.2023.4802" }