Detail publikace

Quantum Material-Based Self-Propelled Microrobots for the Optical "On-the-Fly" Monitoring of DNA

JYOTI, J. MUÑOZ MARTIN, J. PUMERA, M.

Originální název

Quantum Material-Based Self-Propelled Microrobots for the Optical "On-the-Fly" Monitoring of DNA

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Quantum dot-based materials have been found to be excellent platforms for biosensing and bioimaging applications. Herein, self-propelled microrobots made of graphene quantum dots (GQD-MRs) have been synthesized and explored as unconventional dynamic biocarriers toward the optical "on-the-fly" monitoring of DNA. As a first demonstration of applicability, GQD-MRs have been first biofunctionalized with a DNA biomarker (i.e., fluorescein amidite-labeled, FAM-L) via hydrophobic pi-stacking interactions and subsequently exposed toward different concentrations of a DNA target. The biomarker-target hybridization process leads to a biomarker release from the GQD-MR surface, resulting in a linear alteration in the fluorescence intensity of the dynamic biocarrier at the nM range (1-100 nM, R-2 = 0.99), also demonstrating excellent selectivity and sensitivity, with a detection limit as low as 0.05 nM. Consequently, the developed dynamic biocarriers, which combine the appealing features of GQDs (e.g., water solubility, fluorescent activity, and supramolecular pi-stacking interactions) with the autonomous mobility of MRs, present themselves as potential autonomous micromachines to be exploited as highly efficient and sensitive "on-the-fly" biosensing systems. This method is general and can be simply customized by tailoring the biomarker anchored to the GQD-MR's surface.

Klíčová slova

microrockets; fluorescence; self-propelledmicromotors; DNA biosensor; FRET

Autoři

JYOTI, J.; MUÑOZ MARTIN, J.; PUMERA, M.

Vydáno

11. 12. 2023

Nakladatel

AMER CHEMICAL SOC

Místo

WASHINGTON

ISSN

1944-8252

Periodikum

ACS applied materials & interfaces

Ročník

15

Číslo

50

Stát

Spojené státy americké

Strany od

58548

Strany do

58555

Strany počet

8

URL

https://pubs.acs.org/doi/10.1021/acsami.3c09920

Plný text v Digitální knihovně

http://hdl.handle.net/11012/245192

BibTex

@article{BUT186982,
  author="Jyoti {Jyoti} and Jose Maria {Muñoz Martin} and Martin {Pumera}",
  title="Quantum Material-Based Self-Propelled Microrobots for the Optical {"}On-the-Fly{"} Monitoring of DNA",
  journal="ACS applied materials & interfaces",
  year="2023",
  volume="15",
  number="50",
  pages="58548--58555",
  doi="10.1021/acsami.3c09920",
  issn="1944-8252",
  url="https://pubs.acs.org/doi/10.1021/acsami.3c09920"
}