Detail publikace

Abundance of G-Quadruplex Forming Sequences in the Hepatitis Delta Virus Genomes

BRÁZDA, V. VÁLKOVÁ, N. DOBROVOLNÁ, M. MERGNY, J.

Originální název

Abundance of G-Quadruplex Forming Sequences in the Hepatitis Delta Virus Genomes

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Hepatitis delta virus (HDV) is a highly unusual RNA satellite virus that depends on the presence of hepatitis B virus (HBV) to be infectious. Its compact and variable single-stranded RNA genome consists of eight major genotypes distributed unevenly across different continents. The significance of noncanonical secondary structures such as G-quadruplexes (G4s) is increasingly recognized at the DNA and RNA levels, particularly for transcription, replication, and translation. G4s are formed from guanine-rich sequences and have been identified in the vast majority of viral, eukaryotic, and prokaryotic genomes. In this study, we analyzed the G4 propensity of HDV genomes by using G4Hunter. Unlike HBV, which has a G4 density similar to that of the human genome, HDV displays a significantly higher number of potential quadruplex-forming sequences (PQS), with a density more than four times greater than that of the human genome. This finding suggests a critical role for G4s in HDV, especially given that the PQS regions are conserved across HDV genotypes. Furthermore, the prevalence of G4-forming sequences may represent a promising target for therapeutic interventions to control HDV replication.

Klíčová slova

G-quadruplex; HDV; Secondary structures

Autoři

BRÁZDA, V.; VÁLKOVÁ, N.; DOBROVOLNÁ, M.; MERGNY, J.

Vydáno

9. 1. 2024

Nakladatel

American Chemical Society

Místo

WASHINGTON

ISSN

2470-1343

Periodikum

ACS OMEGA

Ročník

9

Číslo

3

Stát

Spojené státy americké

Strany od

4096

Strany do

4101

Strany počet

6

URL

https://pubs.acs.org/doi/10.1021/acsomega.3c09288

Plný text v Digitální knihovně

http://hdl.handle.net/11012/245216

BibTex

@article{BUT187730,
  author="Václav {Brázda} and Natálie {Válková} and Michaela {Dobrovolná} and Jean-Louis {Mergny}",
  title="Abundance of G-Quadruplex Forming Sequences in the Hepatitis Delta Virus Genomes",
  journal="ACS OMEGA",
  year="2024",
  volume="9",
  number="3",
  pages="4096--4101",
  doi="10.1021/acsomega.3c09288",
  issn="2470-1343",
  url="https://pubs.acs.org/doi/10.1021/acsomega.3c09288"
}