Detail publikace

In silico analysis of rutin from ruta chalepensis.L for NF-X1 inhibition in cervical cancer: Insights from HPTLC studies

Rajasekaran, L Pankaj, V Bhogal, I Cejkova, D.

Originální název

In silico analysis of rutin from ruta chalepensis.L for NF-X1 inhibition in cervical cancer: Insights from HPTLC studies

Typ

článek ve sborníku mimo WoS a Scopus

Jazyk

angličtina

Originální abstrakt

Bioactive compounds play a pivotal role in the majority of pharmacological activities. Rutin, in particular, exhibits great potential in combination with antitumor drugs and various herbal formulations, enhancing permeability and regulating apoptosis induction. Earlier studies revealed the presence of alkaloids,flavonoids, phenols, quinines, and steroids among other compounds. Moreover, bioactive compounds were previously identified using GC-MS, with a total of 32 compounds identified within the plant sample Ruta chalepensis L, exhibiting several beneficial effects on leaf extract carried out through antioxidant properties. The leaves of Ruta chalepensis L were previously studied to evaluate the biological constituents and phytochemical screening. In this study, the biologically active compound was performed using high-performance thin-layer chromatography (HPTLC) plates silica gel 60 F 254, with rutin as a standard compound and methanol as a sample solvent. In cervical cancer, NF-X1 is transcriptional repressor which is highly expressed caused by HPV-associated drug compounds, was predicted to bind to rutin compound through in-silico modeling. In conclusion, it was found Rutin could be a potential modulator using molecular docking and simulation studies and has a potential therapeutic role in cervical cancer treatment.

Klíčová slova

Ruta chalepensis. L, Rutin, HPTLC, NF-X1, in silico

Autoři

Rajasekaran, L; Pankaj, V; Bhogal, I; Cejkova, D.

Vydáno

23. 4. 2024

Nakladatel

Brno University of Technology

Místo

Brno, Czech Republic

Strany od

1

Strany do

5

Strany počet

5

BibTex

@inproceedings{BUT188845,
  author="Laxmipriya {Rajasekaran} and Vaishali {Pankaj} and Inderjeet {Bhogal} and Darina {Čejková}",
  title="In silico analysis of rutin from ruta chalepensis.L for NF-X1 inhibition in cervical cancer: Insights from HPTLC studies",
  booktitle="Proceedings I of the 30th STUDENT EEICT 2024",
  year="2024",
  pages="1--5",
  publisher="Brno University of Technology",
  address="Brno, Czech Republic"
}