Detail publikace

Mechanical Properties of Agarose Hydrogels Tuned by Amphiphilic Structures

KADLEC, M. PEKAŘ, M. SMILEK, J.

Originální název

Mechanical Properties of Agarose Hydrogels Tuned by Amphiphilic Structures

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

Agarose is a biocompatible polysaccharide which is able to form physically cross-linked hydrogels in aqueous dispersion. These materials offer a wide range of applications and are commonly used in the food industry or electrophoresis. Moreover, due to their suitable properties (biocompatibility, high water absorption, porosity), agarose hydrogels have recently also found applications also in drug delivery systems, wound dressing, and extracellular matrix (ECM) modelling. In this paper, a comprehensive rheological characterization of agarose hydrogels with various self-assembled amphiphilic structures (CTAB, TTAB, SDS, Tween 20) acting as simple membrane structure models was performed. The results showed that the presence of surfactants of diverse charge above their critical micellar concentration (CMC) can enhance hydrogel mechanical properties. Moreover, pronounced enhancement was observed for cationic surfactant, and even concentrations below CMC resulted in a higher stiffness of the hydrogel. Therefore, both the electrostatic effect and the amphiphilic structure effect can have a significant impact on the rheological properties on agarose hydrogels. These findings are of a great interest in the field of polymer and surfactants interactions, since agarose is widely considered essentially uncharged. However, it is assumed, that traces of negatively charged groups on the agarose backbone can have a significant impact when interacting with oppositely charged surfactants. Moreover, these findings could be beneficial for better understanding of interaction of polysaccharides (e.g. agarose) and self-assembled amphiphilic structures and can also be considered as a crude model of ECM in which membrane structures are embedded.

Klíčová slova

Agarose; hydrogel; surfactant; rheology; stress relaxation

Autoři

KADLEC, M.; PEKAŘ, M.; SMILEK, J.

Vydáno

11. 7. 2024

Nakladatel

Elsevier

Místo

Amsterdam, Nizozemsko

ISSN

0927-7757

Periodikum

Colloids and Surfaces A: Physicochemical and Engineering Aspects

Ročník

700

Číslo

1

Stát

Nizozemsko

Strany počet

14

URL

https://www.sciencedirect.com/science/article/pii/S0927775724016558

BibTex

@article{BUT189041,
  author="Martin {Kadlec} and Miloslav {Pekař} and Jiří {Smilek}",
  title="Mechanical Properties of Agarose Hydrogels Tuned by Amphiphilic Structures",
  journal="Colloids and Surfaces A: Physicochemical and Engineering Aspects",
  year="2024",
  volume="700",
  number="1",
  pages="14",
  doi="10.1016/j.colsurfa.2024.134791",
  issn="0927-7757",
  url="https://www.sciencedirect.com/science/article/pii/S0927775724016558"
}