Detail publikace

A fast all-optical 3D photoacoustic scanner for clinical vascular imaging

HUYNH, N. ZHANG, E. FRANCIES, O. KUKLIŠ, F. ALLEN, T. ZHU, J. ABEYAKOON, O. LUCKA, F. BETCKE, M. JAROŠ, J. ARRIDGE, S. COX, B. PLUMB, A. BEARD, P.

Originální název

A fast all-optical 3D photoacoustic scanner for clinical vascular imaging

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

The clinical assessment of microvascular pathologies (in diabetes and in inflammatory skin diseases, for example) requires the visualization of superficial vascular anatomy. Photoacoustic tomography (PAT) scanners based on an all-optical Fabry-Perot ultrasound sensor can provide highly detailed 3D microvascular images, but minutes-long acquisition times have precluded their clinical use. Here we show that scan times can be reduced to a few seconds and even hundreds of milliseconds by parallelizing the optical architecture of the sensor readout, by using excitation lasers with high pulse-repetition frequencies and by exploiting compressed sensing. A PAT scanner with such fast acquisition minimizes motion-related artefacts and allows for the volumetric visualization of individual arterioles, venules, venous valves and millimetre-scale arteries and veins to depths approaching 15mm, as well as for dynamic 3D images of time-varying tissue perfusion and other haemodynamic events. In exploratory case studies, we used the scanner to visualize and quantify microvascular changes associated with peripheral vascular disease, skin inflammation and rheumatoid arthritis. Fast all-optical PAT may prove useful in cardiovascular medicine, oncology, dermatology and rheumatology.

Klíčová slova

Photoacoustic imaging, Fabry-Perot ultrasound sensor, image reconstruction, real-time imaging.

Autoři

HUYNH, N.; ZHANG, E.; FRANCIES, O.; KUKLIŠ, F.; ALLEN, T.; ZHU, J.; ABEYAKOON, O.; LUCKA, F.; BETCKE, M.; JAROŠ, J.; ARRIDGE, S.; COX, B.; PLUMB, A.; BEARD, P.

Vydáno

30. 9. 2024

ISSN

2157-846X

Periodikum

Nature Biomedical Engineering

Ročník

8

Číslo

10

Stát

Spojené království Velké Británie a Severního Irska

Strany od

1

Strany do

18

Strany počet

18

URL

https://www.fit.vut.cz/research/publication/12979/

BibTex

@article{BUT189851,
  author="HUYNH, N. and ZHANG, E. and FRANCIES, O. and KUKLIŠ, F. and ALLEN, T. and ZHU, J. and ABEYAKOON, O. and LUCKA, F. and BETCKE, M. and JAROŠ, J. and ARRIDGE, S. and COX, B. and PLUMB, A. and BEARD, P.",
  title="A fast all-optical 3D photoacoustic scanner for clinical vascular imaging",
  journal="Nature Biomedical Engineering",
  year="2024",
  volume="8",
  number="10",
  pages="1--18",
  doi="10.1038/s41551-024-01247-x",
  issn="2157-846X",
  url="https://www.fit.vut.cz/research/publication/12979/"
}

Dokumenty

19243_0_art_file_143024_rx87pp.pdf
Multi_beam_scanner_plan_11_AP_NTH_2-2.docx
Scanner-Final.pdf