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HÁJEK, D. KOLÁŘ, P. MAINI, P. ŠTARHA, P.
Originální název
Extracellular volume regulation and growth
Typ
článek v časopise - ostatní, Jost
Jazyk
angličtina
Originální abstrakt
We have formalized extracellular and intracellular volume interaction with each other and the influence of these processes on the type of cell growth. The linearized model was verified by stereo metric solution and the results were compared with experimental data. Two theoretical solutions were found: Solution 1, extracellular volume (ECV) was calculated to be about 23% of total body volume (TV). Stereo metric solution suggested the cubic cell cluster formed by 8-cells. This hypothesis (Solution 1) explains the ECV to be compatible with the widely accepted value (about 23% of TV). In addition, the 8-cell cluster hypothesis explains the existence of ECV oscillation with the period of about seven days. This hypothesis probably describes the dominant type of growth in humans. Solution 2, in this type of growth, ECV fills about 77% of TV. Instead of the 8-cell cube, in this type of proliferation 4-cells could form a tetrahedron. This type of growth could be beneficial in processes where free space in tissue or organ must be fitted for example in peptic ulcer heating and namely in repopulating of free space in a bone after high dose chemotherapy. (C) 2004 Elsevier Ltd. All rights reserved.
Klíčová slova
volume interaction cell growth stereo metric solution extracellular volume (ECV)
Autoři
HÁJEK, D.; KOLÁŘ, P.; MAINI, P.; ŠTARHA, P.
Rok RIV
2005
Vydáno
1. 3. 2005
Nakladatel
CHURCHILL LIVINGSTONE
Místo
MIDLOTHIAN, SCOTLAND
ISSN
0306-9877
Periodikum
Medical Hypotheses
Ročník
64
Číslo
2
Stát
Spojené království Velké Británie a Severního Irska
Strany od
303
Strany do
306
Strany počet
4
BibTex
@article{BUT43423, author="Dobroslav {Hájek} and Petr {Kolář} and PK {Maini} and Pavel {Štarha}", title="Extracellular volume regulation and growth", journal="Medical Hypotheses", year="2005", volume="64", number="2", pages="303--306", issn="0306-9877" }