Detail publikace

Insight to Physiology and Pathology of Zinc(II) Ions and Their Actions in Breast and Prostate Carcinoma

GUMULEC, J. MASAŘÍK, M. KŘÍŽKOVÁ, S. ADAM, V. HUBÁLEK, J. HRABĚTA, J. ECKSCHLAGER, T. STIBOROVÁ, M. KIZEK, R.

Originální název

Insight to Physiology and Pathology of Zinc(II) Ions and Their Actions in Breast and Prostate Carcinoma

Typ

článek v časopise ve Web of Science, Jimp

Jazyk

angličtina

Originální abstrakt

MT protects cells against oxidative stress, because it cooperates with reduced glutathione (GSH). Recent studies indicate elevated serum level of MT in a number of malignancies, among others in breast, and prostate. MT together with zinc(II) affect apoptosis and proliferation, thus together with its antioxidative effects it may affect cancer. To date, only little is known about the influence of zinc(II) and MT on cancer, while these compounds may play an important role in pathogenesis. This review concludes current data regarding the impact of zinc(II) on the pathogenesis of breast and prostate cancers with potential outlines of new, targeted therapy and prevention. Moreover, blood plasma zinc(II) and MT levels and dietary zinc(II) intake are discussed in relation to breast and prostate cancer risk.

Klíčová slova

Zinc, Cancer, Prostate Carcinoma, Breast Carcinoma, Homeostasis, Low Molecular Mass Thiols, Metallothionein, Glutathione, Zinc Intake, Apoptosis, ZnT and ZIP transporters

Autoři

GUMULEC, J.; MASAŘÍK, M.; KŘÍŽKOVÁ, S.; ADAM, V.; HUBÁLEK, J.; HRABĚTA, J.; ECKSCHLAGER, T.; STIBOROVÁ, M.; KIZEK, R.

Rok RIV

2011

Vydáno

1. 11. 2011

ISSN

0929-8673

Periodikum

CURRENT MEDICINAL CHEMISTRY

Ročník

2011 (18)

Číslo

33

Stát

Stát Spojené arabské emiráty

Strany od

5041

Strany do

5051

Strany počet

11

BibTex

@article{BUT75099,
  author="GUMULEC, J. and MASAŘÍK, M. and KŘÍŽKOVÁ, S. and ADAM, V. and HUBÁLEK, J. and HRABĚTA, J. and ECKSCHLAGER, T. and STIBOROVÁ, M. and KIZEK, R.",
  title="Insight to Physiology and Pathology of Zinc(II) Ions and Their Actions in Breast and Prostate Carcinoma",
  journal="CURRENT MEDICINAL CHEMISTRY",
  year="2011",
  volume="2011 (18)",
  number="33",
  pages="5041--5051",
  issn="0929-8673"
}